Bacterial/Permeability-Increasing Protein, Human Neutrophil (BPI, CAP57)
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Catalog number
7288-100
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Price
Please ask
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Size
100 ug
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Synonyms
BPI, CAP57
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Alternative_names
BPI, CAP57
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Description
An endogenous antibiotic protein with potent killing activity against Gram-negative bacteria
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Recombinant
No
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Source
Human Neutrophil
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Molecular Weight
55 kDa
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Storage Temp
-80°C
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Shipping
Dry Ice
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Shelf Life
12 months
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Appearance
Frozen
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Physical form description
Frozen in 80 mM Citrate Phosphate, pH 5.6, 0.75 M NaCl.
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Background Information
Bactericidal/permeability increasing protein (BPI) is a 456 residue protein which is part of the innate immune system. BPI was initially identified in neutrophils, but is found in other tissues including the epithelial lining of mucus membranes. It is an endogenous antibiotic protein with potent killing activity against Gram-negative bacteria. It binds to compounds called lipopolysaccharides produced by Gram-negative bacteria. Lipolysaccharides are potent activators of the immune system; however BPI at certain concentrations can prevent this activation. Bacterial/Permeability-Increasing Protein (BPI) is present in the azurophilic granules of polymorphonuclear leukocytes (PMN). BPI is toxic only toward Gram-negative bacteria. This specificity is attributable to the strong attraction of BPI for the lipopolysaccharides (LPS) in the bacterial envelope. BPI is also an important antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in vasculitis.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Gene symbol
BPI
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Short name
Bacterial/Permeability-Increasing Protein, Neutrophil (BPI, CAP57)
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Species
Human, Humans
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Alternative name
Bacterial/Permeability-Increasing Protein, H. sapiens Neutrophil (bactericidal/permeability-increasing protein, CAP57)
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Alternative to gene target
bactericidal/permeability-increasing protein, BPIFD1 and rBPI, BPI and IDBG-74654 and ENSG00000101425 and 149684,671, lipid binding, Plasma membranes, Bpi and IDBG-211473 and ENSMUSG00000052922 and 329547, BPI and IDBG-642592 and ENSBTAG00000014046 and 280734
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Gene info
MeSH Data
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Name
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Concept
Scope note:
Radioimmunoassay of proteins using antibody coupled to an immunosorbent.
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Tree numbers
- E05.478.566.380.830
- E05.478.566.639.830
- E05.601.470.380.830
- E05.601.470.639.830
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Qualifiers
ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data
Product images
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