CD45/ LCA Antibody

• Catalog number
  GEN438149
• Price
  Please ask
• Size
  100ug

• Also known as
  CD45
• Other names
  receptor-type tyrosine-protein phosphatase C isoform 1; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; CD45 antigen; T200 glycoprotein; T200 leukocyte common antigen; protein tyrosine phosphatase, receptor type, c polypeptide; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; T200; CD_antigen: CD45
• Category
  Antibodies
• Subcategory
  Mnoclonal antibodies
• Gene name
  PTPRC
• Gene name synonims
  N/A
• Other gene names
  PTPRC; PTPRC; LCA; LY5; B220; CD45; L-CA; T200; CD45R; GP180; CD45; L-CA
• Clonality
  Monoclonal
• Immunoglobulin isotype
  IgG1, kappa + IgG1, kappa
• Clone
  SPM569 + SPM570
• Host organism
  Mouse (Mus musculus)
• Species reactivity
  Human (Homo sapiens).; Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
• Specificity and cross reactivity
  Recognizes the CD45 leukocyte common antigen (LCA) family which is comprised of at least four isoforms of membrane glycoproteins (220, 205, 190, 180kDa) expressed on hematopoietic cell lines but absent on non-hematopoietic cell lines, normal and malignant non-hematopoietic tissues. The intracellular portions of these molecules have protein phosphatase activity and are involved in regulation of transmembrane signals. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms. A positive result with this MAb is highly indicative of lymphoid or myeloid origin. Certain types of lymphoid neoplasms may lack CD45 (Hodgkin lymphoma, some T-cell lymphomas, and some leukemias) so its absence does not rule out a hematolymphoid tumor. This antibody is expressed almost exclusively by cells of hematopoietic lineage and is present in most benign and malignant lymphocytes as well as plasma cell precursors.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
• Purification method
  N/A
• Form Appearance
  N/A
• Concentration
  N/A
• Storage and shipping
  Store the antibody at +4C. Temperature variations in the range of 1 to 7 degrees Celsius are tolerable. We recommend NOT to freeze the antibody. Antibody is stable for 24 months.
• Tested applications
  Flow Cytometry (FC/FACS), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), Immunohistology (IH)
• Properties
  If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CD45   LCA  
• Gene symbol
  PTPRC, CLTA, PTPRCAP, GUCY2D
• Short name
  CD45/ LCA Antibody
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Alternative name
  Anti-CD45/ LCA
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9666
• Gene
  PTPRC
• Long gene name
  protein tyrosine phosphatase receptor type C
• Synonyms gene
  • CD45
• Synonyms
  • LCA
  • T200
  • GP180
• GenBank acession
  • Y00062
• Locus
  1q31.3-q32.1
• Discovery year
  1986-01-01
• Entrez gene record
  5788
• Pubmed identfication
  • 2169617
• RefSeq identity
  • NM_002838
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
  • CD molecules
• VEGA ID
  OTTHUMG00000035702
• Locus Specific Databases
  • PTPRCbase: Mutation registry for CD45 deficiency
  • LRG_95

Gene info

• Identity
  HGNC:2090
• Gene
  CLTA
• Long gene name
  clathrin light chain A
• Synonyms gene name
  • clathrin, light polypeptide (Lca)
  • clathrin, light chain A
• Synonyms
  • Lca
• Locus
  9p13.3
• Discovery year
  1991-08-08
• Entrez gene record
  1211
• Pubmed identfication
  • 7713494
• RefSeq identity
  • NM_007096
• Classification
  • Clathrin subunits
• VEGA ID
  OTTHUMG00000019896

Gene info

• Identity
  HGNC:9667
• Gene
  PTPRCAP
• Long gene name
  protein tyrosine phosphatase receptor type C associated protein
• Synonyms
  • LPAP
  • CD45-AP
• Locus
  11q13.2
• Discovery year
  1996-04-22
• Entrez gene record
  5790
• RefSeq identity
  • NM_005608
• VEGA ID
  OTTHUMG00000150325

Gene info

• Identity
  HGNC:4689
• Gene
  GUCY2D
• Long gene name
  guanylate cyclase 2D, retinal
• Synonyms gene
  • CORD6
  • LCA
  • GUC2D
  • GUC1A4
• Synonyms gene name
  • cone rod dystrophy 6
  • guanylate cyclase 2D, membrane (retina-specific)
• Synonyms
  • retGC
  • RETGC-1
  • ROS-GC1
  • CYGD
  • LCA1
• Synonyms name
  • rod outer segment membrane guanylate cyclase
  • retinal guanylate cyclase 1
• GenBank acession
  • L26921
• Locus
  17p13.1
• Discovery year
  1993-11-09
• Entrez gene record
  3000
• Pubmed identfication
  • 1356371
  • 12552567
• RefSeq identity
  • NM_000180
• Classification
  • Guanylate cyclase receptors
• VEGA ID
  OTTHUMG00000108169
• Locus Specific Databases
  • Mutations of the Retinal Guanylate Cyclase Gene and the Retinal Guanylate Cyclase-activating Protein Gene

MeSH Data

• Name
  CD4 Lymphocyte Count
• Concept
  Scope note: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
• Tree numbers
  • E01.370.225.500.195.107.595.500.150
  • E01.370.225.625.107.595.500.150
  • E05.200.500.195.107.595.500.150
  • E05.200.625.107.595.500.150
  • E05.242.195.107.595.500.150
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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