Dipeptidylpeptidase IV, human recombinant
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Catalog number4710-1000
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PricePlease ask
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Size1 mg
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SynonymsCD26, ADABP, ADCP2, DPPIV, TP103, DPP4, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, CD26 antigen.
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Alternative_namesCD26, ADABP, ADCP2, DPPIV, TP103, DPP4, Dipeptidyl peptidase 4, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, Adenosine deaminase complexing protein 2, CD26 antigen.
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DescriptionAn antigenic enzyme associated with immune regulation, signal transduction and apoptosis.
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RecombinantYes
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SourceHigh-5 cells
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Purity by SDS PAGE≥95%
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AssaySDS-PAGE
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Activity Specifications test method>20 Units/mg
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Biological activity>20 Units/mg
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Unit DefinitionOne unit will hydrolyze 1 mmole of p-nitroaniline per minute at pH 8.0 at 37°C using 1mM of Gly-Pro p-nitroanilde as a substrate.
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Molecular Weight86.4 kDa
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Storage Temp-20°C
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ShippingGel pack
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Shelf Life12 months
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AppearanceLiquid
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Physical form description0.5 mg/ml; Sterile filtered solution containing 20 mM Tris-HCl buffer pH 8.0,100 mM NaCl, 1 mM EDTA and 10 % glycerol.
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Background InformationDPP4 is a serine exopeptidase and complex enzyme that is expressed on the surface of most cell types as an intrinsic membrane glycoprotein that cleaves X-proline dipeptides from the N-terminus of polypeptides and plays a role in t-cell activation. DPP4 is associated with intracellular signal transduction, apoptosis and involved in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). DPP4 Human Recombinant is a single, glycosylated polypeptide chain containing 746 amino acids (aa 39-766) with a C-terminal His-tag and is purified using conventional chromatography techniques.
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Amino acid sequenceADP-SRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP-SGRLVPRGSHHHHHH
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolDPP4, DPP8
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Short nameDipeptidylpeptidase IV, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameDipeptidylpeptidase IV, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namedipeptidyl peptidase 4
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Synonyms gene
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Synonyms gene name
- dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
- adenosine deaminase complexing protein 2
- dipeptidyl-peptidase 4
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Synonyms
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GenBank acession
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Locus
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Discovery year1990-03-05
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Entrez gene record
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Pubmed identfication
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Classification
- CD molecules
- DASH family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namedipeptidyl peptidase 8
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Synonyms gene name
- dipeptidylpeptidase 8
- dipeptidyl-peptidase 8
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-09-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- DASH family
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data