Synonyms
Gremlin 2
Alternative_names
Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, Protein related to DAN and cerberus, DAN domain family member 3
Description
Inhibitor of BMP-2, -4, and -7
Recombinant
Yes
Source
E. coli
Purity by SDS-PAGE
≥95%
Assay
SDS-PAGE
Purity
≥95%
Biological activity
Test in process
Molecular Weight
17.2 kDa
Storage Temp.
-20°C
Shipping
Blue ice
Shelf Life
12 months
Appearance
Lyophilized protein
Physical form description
Sterile filtered and lyophilized with no additives
Reconstitution Instructions
Reconstitute to 1 mg/ml with sterilized dH₂O. Pipette to dissolve the protein pellet completely
Background Information
Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli.
Handling
Centrifuge the vial prior to opening.
Usage
For Research Use Only! Not to be used in humans
Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Additional source
Recombinants or rec. proteins
Group
recombinants
Gene targetGremlin
Short name
Gremlin 2, recombinant
Technique
Recombinant
Species
Human
Alternative name
Gremlin 2, H. sapiens recombinant
Alternative technique
rec
