S-Adenosyl-L-methionine disulfate tosylate

Alternative_name

AdoMet SAM disulfate p-toluenesulfonate; SAMe
Description

A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.
CAS Number

97540-22-2
Structure Available

Yes
Molecular Formula

C₁₅H₂₂N₆O₅S.C₇H₁₂O₁₁S₂
Molecular Weight

766.8
Cell Permeable

No
Purity

≥95% by HPLC
Solubilities

H₂O (~100 mg/ml)
Handling

Protect from moisture
Tag Line

A cofactor for catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT)
Storage Condition

-20°C
Shipping Condition

Dry ice
Shelf Life

24 months
MDL Number

MFCD01674068
PubChem CID

163657
PubChem CID Link
SMILES

CC1=CC=C(C=C1)S(=O)(=O)[O-].C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C2N= CN=C3N)O)O.OS(=O)(=O)[O-].[O-]S(=O)(=O)[O-]
InChi

InChI=1S/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11 (23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8, 9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24, 25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/p-3/t7-,8+,10+,11+,14+, 27?;;;/m0.../s1
InChi Key

XDCFCHNAIMYBAZ-XQVUROGGSA-K
Data Sheet Link
MSDS Available

Yes

Gene target

S-Adenosyl-L-methionine disulfate tosylate
Gene symbol

CPT1A, POM121L2, L3MBTL2, CLDN10, RPL32P1, FABP1, COX7A2, NFIA, MAS1L, ANP32E
Short name

S-Adenosyl-L-methionine disulfate tosylate
Alternative name

S-Adenosyl-L-methionine disulfate tosylate

Identity

HGNC:13973
Gene

POM121L2
Long gene name

POM121 transmembrane nucleoporin like 2
Synonyms gene name
- POM121 membrane glycoprotein-like 2 (rat)
- POM121 membrane glycoprotein-like 2
- POM121 transmembrane nucleoporin-like 2
Synonyms
- POM121-L
GenBank acession
- AL021808
Locus

6p22.1
Discovery year

2001-07-20
Entrez gene record

94026
RefSeq identity
- NM_033482
VEGA ID

OTTHUMG00000014475

Identity

HGNC:18594
Gene

L3MBTL2
Long gene name

L3MBTL histone methyl-lysine binding protein 2
Synonyms gene name
- l(3)mbt-like 2 (Drosophila)
- L3MBTL2, polycomb repressive complex 1 subunit
Synonyms
GenBank acession
- AJ305226
Locus

22q13.2
Discovery year

2002-04-29
Entrez gene record

83746
Pubmed identfication
- 11682070
- 21596310
RefSeq identity
- NM_031488
Classification
- MBT domain containing
VEGA ID

OTTHUMG00000150942

Identity

HGNC:16673
Gene

ANP32E
Long gene name

acidic nuclear phosphoprotein 32 family member E
Synonyms gene name
- acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
Synonyms
- LANPL
- MGC5350
- LANP-L
GenBank acession
- AK092672
Locus

1q21.2
Discovery year

2003-04-15
Entrez gene record

81611
Pubmed identfication
- 12438741
RefSeq identity
- NM_030920
Classification
- ANP32 acidic nuclear phosphoproteins
VEGA ID

OTTHUMG00000012547