MK-0752

Alternative_name

3-[4-(4-chlorophenyl)sulfonyl-4-(2,5-difluorophenyl)cyclohexyl]propanoic acid
Description

MK-0752 is a potent and reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells (IC₅₀ = 5 nM). Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel (Cat. No. 2232) in mice with breast cancer tumors.
CAS Number

471905-41-6
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₁H₂₁ClF₂O₄S
Molecular Weight

442.9
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (>20 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and reversible γ-secretase inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

9803433
PubChem CID Link
SMILES

C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
InChi

InChI=1S/C21H21ClF2O4S/c22-15-2-5-17(6-3-15)29(27,28)21(18-13-16(23)4-7-19(18)24)11-9-14(10-12-21)1-8-20(25)26/h2-7,13-14H,1,8-12H2,(H,25,26)
InChi Key

XCGJIFAKUZNNOR-UHFFFAOYSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:7530
Gene

MVK
Long gene name

mevalonate kinase
Synonyms gene name
- mevalonate kinase (mevalonic aciduria)
Synonyms
- LRBP
- MK
Synonyms name
- LH receptor mRNA-binding protein
- mevalonic aciduria
GenBank acession
- M88468
Locus

12q24.11
Discovery year

1992-10-06
Entrez gene record

4598
Pubmed identfication
- 1377680
RefSeq identity
- NM_000431
VEGA ID

OTTHUMG00000169256
Locus Specific Databases
- INFEVERS: The repertory of Familial Mediterranean Fever (FMF) and Hereditary Inflammatory Disorders Mutations
- LRG_156

Identity

HGNC:6888
Gene

MAPKAPK3
Long gene name

MAPK activated protein kinase 3
Synonyms gene name
- mitogen-activated protein kinase-activated protein kinase 3
Synonyms
- 3pK
- MAPKAP3
- 3PK
- MK-3
- MK3
GenBank acession
- U43784
Locus

3p21.2
Discovery year

1999-03-26
Entrez gene record

7867
Pubmed identfication
- 8626550
- 8622688
RefSeq identity
- NM_004635
Classification
- MAPK activated protein kinases
VEGA ID

OTTHUMG00000156850

Identity

HGNC:11529
Gene

EPCAM
Long gene name

epithelial cell adhesion molecule
Synonyms gene
- M4S1
- MIC18
- TACSTD1
Synonyms gene name
- antigen identified by monoclonal antibody AUA1
- tumor-associated calcium signal transducer 1
Synonyms
- Ly74
- TROP1
- GA733-2
- EGP34
- EGP40
- EGP-2
- KSA
- CD326
- Ep-CAM
- HEA125
- KS1/4
- MK-1
- MH99
- MOC31
- MOC-31
- 323/A3
- 17-1A
- TACST-1
- CO-17A
- ESA
- BerEp4
- Ber-Ep4
Synonyms name
- trophoblast cell surface antigen 1
GenBank acession
- M33011
Locus

2p21
Discovery year

1995-10-02
Entrez gene record

4072
Pubmed identfication
- 8382772
- 11306819
Classification
- MicroRNA protein coding host genes
- CD molecules
VEGA ID

OTTHUMG00000128853
Locus Specific Databases
- Global Variome shared LOVD
- LRG_215