ABL1+2(Tyr393+439) Antibody, ALEXA FLUOR 594

• Catalog number
  bs-8440R-A594
• Price
  Please ask
• Size
  100ul

• Long name
  ABL1+2(Tyr393+439) Polyclonal Antibody, ALEXA FLUOR 594 Conjugated
• Also known as
  Anti-ABL1+2Tyr393+439 PAb ALEXA FLUOR 594
• Category
  Conjugated Primary Antibodies
• Conjugated with
  ALEXA FLUOR® 594
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  ABL1+2Tyr393+439
• Specificity
  This is a highly specific antibody against ABL1+2Tyr393+439.
• Modification
  Phosphorylation
• Modification Site
  Tyr393+439
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human c-Abl around the phosphorylation site of Tyr393
• Gene ID Number
  25
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the antigen
  The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq].
• Purification
  Purified by Protein A.
• Storage conditions
  Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
• Excitation emission
  590nm/617nm
• Synonyms
  c Abl (phospho Y412) (isoform b); phospho-c-ABL1 (Try412) (isoform b); c-Abl 1/2(phospho Y393/429); c-ABL1/2(phospho Tyr393/429); p-c-ABL1/2(Tyr393/429); tyrosine-protein kinase ABL1 isoform b; Abelson Murine Leukemia Viral Oncogene Homolog 1; Abelson murine leukemia viral v abl oncogene homolog 1; Abl 1; ABL; Abl protein; Abl1; Bcr/c abl oncogene protein; JTK 7; JTK7; p150 ; Proto oncogene tyrosine protein kinase ABL1; Transformation gene oncogene ABL; v abl Abelson murine leukemia viral oncogene homolog 1; v abl; ABL1_HUMAN.
• Properties
  For facs or microscopy Alexa 1 conjugate. If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• French translation
  anticorps

• Gene target
  ABL1+2   Tyr393+439  
• Gene symbol
  ABL1
• Short name
  Anti-ABL1+2Tyr393+439
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  ABL1+2(Tyr393+439) Polyclonal Antibody, ALEXA FLUOR 594
• Alternative technique
  antibodies
• Alternative to gene target
  c-abl oncogene 1, non-receptor tyrosine kinase, ABL and bcr/abl and c-ABL and c-ABL1 and JTK7 and p150 and v-abl, ABL1 and IDBG-89599 and ENSG00000097007 and 25, transferase activity, nuclei, Abl1 and IDBG-158216 and ENSMUSG00000026842 and 11350, ABL1 and IDBG-639939 and ENSBTAG00000017976 and 540876

Gene info

• Identity
  HGNC:76
• Gene
  ABL1
• Long gene name
  ABL proto-oncogene 1, non-receptor tyrosine kinase
• Synonyms gene
  • ABL
• Synonyms gene name
  • v-abl Abelson murine leukemia viral oncogene homolog 1
  • c-abl oncogene 1, receptor tyrosine kinase
  • c-abl oncogene 1, non-receptor tyrosine kinase
• Synonyms
  • JTK7
  • c-ABL
  • p150
• GenBank acession
  • M14752
• Locus
  9q34.12
• Discovery year
  1986-01-01
• Entrez gene record
  25
• Pubmed identfication
  • 1857987
  • 12626632
• RefSeq identity
  • NM_007313
• Classification
  • Abl family tyrosine kinases
  • SH2 domain containing
• VEGA ID
  OTTHUMG00000020813
• Locus Specific Databases
  • LRG_769

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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