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Trk B Antibody ALEXA FLUOR

Trk B Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-0288R-A350 | Trk B Antibody, ALEXA FLUOR 350 size: 100ul | 441.94 USD

Catalog number bs-0288R-A350
Price 441.94 USD
Size 100ul
Long name Trk B Polyclonal Antibody, ALEXA FLUOR 350 Conjugated
Also known as Anti-TrkB PAb ALEXA FLUOR 350
Conjugated with ALEXA FLUOR® 350
Excitation emission 343nm/442nm
Properties For facs or microscopy Alexa 1 conjugate.Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR 350
French translation anticorps
Alternative name Trk B Polyclonal Antibody, ALEXA FLUOR 350
Product images
    #.png#bs#.jpgFormalin-fixed and paraffin embedded: rat brain tissue labeled with Anti-TrkB Polyclonal Antibody, Unconjugated (bs-0288R) at 1:200, followed by conjugation to the secondary antibody and DAB staining
Product files

bs-0288R-A488 | Trk B Antibody, ALEXA FLUOR 488 size: 100ul | 441.94 USD


bs-0288R-A555 | Trk B Antibody, ALEXA FLUOR 555 size: 100ul | 441.94 USD


bs-0288R-A594 | Trk B Antibody, ALEXA FLUOR 594 size: 100ul | 441.94 USD


bs-0288R-A647 | Trk B Antibody, ALEXA FLUOR 647 size: 100ul | 441.94 USD

Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Target Antigen TrkB
Specificity This is a highly specific antibody against TrkB.
Modification Unmodified
Modification Site None
Clonality Polyclonal
Clone Polyclonal antibody
Concentration 1ug per 1ul
Immunogen range 30-80/822
Subcellular location Extracellular
Source This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Trk B
Gene ID Number 4915
Swiss Prot Q16620
Tested applications IF(IHC-P)
Recommended dilutions IF(IHC-P)(1:50-200)
Crossreactivity Human, Mouse, Rat
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Background of the antigen Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Purification Purified by Protein A.
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Synonyms TRKB; trk-B; GP145-TrkB; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; Tropomyosin-related kinase B; NTRK2
Gene targetTrk
Short name Anti-TrkB
Technique Antibody
Isotype Immunoglobulin G (IgG)
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Anti-TrkB | Technique alternative | 01011191689
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
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