anti-JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody

• Catalog number
  79-504
• Price
  Please ask
• Size
  0.1 mg

• Gene info
  Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it./Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity
• Gene names
  JNK, JNK1, PRKM8, SAPK1, JNK-46, JNK1A2, SAPK1c, JNK21B1/2, FLT, FRT, VEGFR1, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1
• Antibodie s label
  unlabelled serum
• Purity
  Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Spicific to
  This antibody detects endogenous level of JNK1/JNK2 only when phosphorylated at Thr183/Tyr185.
• Antigen
  JNK1/JNK2 (phospho-Thr183/Tyr185) antibody was made against a peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T (p) -P-Y (p) - V - V ) derived from Human JNK1/JNK2.
• Immuno application
  Western Blot, immuno fluorescence
• Antibody advice
  Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200
• Suspention pH azide
  Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Keep at
  Store antibody at -20 grades C for up to one year.
• Works with
  Human, Mouse, Rat
• Omim nr
  4506095 / 205277412 / 4506081
• Ncbi nr
  NP_002741.1 / NP_001128516.1 / NP_002744.1
• KDa
  46, 54 kDa
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  5599 / 5601 / 5602
• GENE symbol
  MAPK8 MAPK9 MAPK10
• Antigene name
  mitogen-activated protein kinase 8 / mitogen-activated protein kinase 9 / mitogen-activated protein kinase 10
• Source
  Homo sapiens
• Protein nr
  P45983 P45984 P53779
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  JNK1   JNK2   phospho   Thr183   Tyr185  
• Gene symbol
  MAPK8, MAPK9
• Short name
  anti-JNK1 / JNK2 (phospho Thr183 / Tyr185) Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toJNK1 / JNK2 (phosphorilated Thr183 / Tyr185) (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:6881
• Gene
  MAPK8
• Long gene name
  mitogen-activated protein kinase 8
• Synonyms gene
  • PRKM8
• Synonyms
  • JNK
  • JNK1
  • SAPK1
• Synonyms name
  • JUN N-terminal kinase
• GenBank acession
  • L26318
• Locus
  10q11.22
• Discovery year
  1998-04-28
• Entrez gene record
  5599
• Pubmed identfication
  • 8137421
  • 8654373
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000018172

Gene info

• Identity
  HGNC:6886
• Gene
  MAPK9
• Long gene name
  mitogen-activated protein kinase 9
• Synonyms gene
  • PRKM9
• Synonyms
  • JNK2
  • p54a
  • SAPK
• Synonyms name
  • Jun kinase
• GenBank acession
  • U09759
• Locus
  5q35.3
• Discovery year
  1998-04-28
• Entrez gene record
  5601
• Pubmed identfication
  • 8001819
• Classification
  • Mitogen-activated protein kinases
• VEGA ID
  OTTHUMG00000130934

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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