Tweak Receptor (TWEAK R, TWEAKR, CD266, Fibroblast Growth Factor-inducible Immediate Early Response Protein 14, FGF-inducible 14, FN14, Tumor Necrosis Factor Receptor Superfamily Member 12A, TNFRSF12A, Type I Transmembrane Protein Fn14)[Tweak Receptor]

• Catalog number
  MBS606293
• Price
  Please ask
• Size
  NA

• Products_type
  Antibody
• Reactivity
  Human, Mouse, Rat
• Description
  Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  Tweak   Receptor   TWEAK   TWEAKR   CD266   Fibroblast   Growth   Factor   Immediate   Early   Response   Protein   FGF   FN14   Tumor   Necrosis   Factor   Receptor   Superfamily   Member   12A   TNFRSF12A   Transmembrane   Protein   Fn14   [Tweak   Receptor]  
• Gene symbol
  TNFRSF12A, TNFSF12, FGF18, FGF17, IL12A, NUDT6, FGF4, FGF1
• Short name
  Tweak Receptor (TWEAK R, TWEAKR, CD266, Fibroblast Growth Factor- Immediate Early Response Protein 14, FGF- 14, FN14, Tumor Necrosis Factor Receptor Superfamily Member 12A, TNFRSF12A, I Transmembrane Protein Fn14)[Tweak Receptor]
• Host
  Mouse
• Alternative name
  Tweak Receptor (TWEAK R, TWEAKR, CD266, Fibroblast Growth Factor-inducible Immediate Early Response Protein 14, FGF-inducible 14, FN14, Tumor Necrosis Factor Receptor supergroup Member 12A, tumor necrosis factor receptor superfamily, member 12A, classification I Transmembrane Protein Fn14)[Tweak Receptor]
• Alternative to gene target
  tumor necrosis factor receptor superfamily, member 12A, TNFRSF12A and IDBG-11328 and ENSG00000006327 and 51330, protein binding, Cell surfaces, Tnfrsf12a and IDBG-143687 and ENSMUSG00000023905 and 27279, BT.20111 and IDBG-635818 and ENSBTAG00000012082 and 617439
• Tissue
  tumor

Gene info

• Identity
  HGNC:18152
• Gene
  TNFRSF12A
• Long gene name
  TNF receptor superfamily member 12A
• Synonyms gene name
  • tumor necrosis factor receptor superfamily, member 12A
• Synonyms
  • FN14
  • TweakR
  • CD266
• GenBank acession
  • AB035480
• Locus
  16p13.3
• Discovery year
  2002-12-20
• Pubmed identfication
  • 10751351
  • 10551889
• Classification
  • Tumor necrosis factor receptor superfamily
  • CD molecules
• VEGA ID
  OTTHUMG00000129001

Gene info

• Identity
  HGNC:11927
• Gene
  TNFSF12
• Long gene name
  TNF superfamily member 12
• Synonyms gene name
  • tumor necrosis factor (ligand) superfamily, member 12
• Synonyms
  • TWEAK
  • DR3LG
  • APO3L
• GenBank acession
  • AF030099
• Locus
  17p13.1
• Discovery year
  1998-12-04
• Entrez gene record
  8742
• Pubmed identfication
  • 9405449
  • 9560343
• RefSeq identity
  • NM_003809
• Classification
  • Tumor necrosis factor superfamily
• VEGA ID
  OTTHUMG00000108148
• Locus Specific Databases
  • LRG_1320

Gene info

• Identity
  HGNC:3674
• Gene
  FGF18
• Long gene name
  fibroblast growth factor 18
• Synonyms
  • FGF-18
  • ZFGF5
• GenBank acession
  • AB007422
• Locus
  5q35.1
• Discovery year
  1998-12-22
• Entrez gene record
  8817
• Pubmed identfication
  • 9660775
  • 9742123
• RefSeq identity
  • NM_033649
  • NM_003862
• Classification
  • Fibroblast growth factor family
• VEGA ID
  OTTHUMG00000130464

Gene info

• Identity
  HGNC:3673
• Gene
  FGF17
• Long gene name
  fibroblast growth factor 17
• Synonyms
  • FGF-13
• GenBank acession
  • AB009249
• Locus
  8p21.3
• Discovery year
  1998-12-22
• Entrez gene record
  8822
• Pubmed identfication
  • 9514906
  • 9751161
• RefSeq identity
  • NM_003867
• Classification
  • Fibroblast growth factor family
• VEGA ID
  OTTHUMG00000097051

Gene info

• Identity
  HGNC:5969
• Gene
  IL12A
• Long gene name
  interleukin 12A
• Synonyms gene
  • NKSF1
• Synonyms gene name
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)
• Synonyms
  • CLMF
  • IL-12A
  • p35
  • NFSK
• Synonyms name
  • natural killer cell stimulatory factor 1, 35 kD subunit
  • cytotoxic lymphocyte maturation factor 1, p35
  • interleukin 12, p35
  • IL-12, subunit p35
  • NF cell stimulatory factor chain 1
  • interleukin-12 alpha chain
  • IL35 subunit
• GenBank acession
  • M65271
• Locus
  3q25.33
• Discovery year
  1991-08-08
• Entrez gene record
  3592
• Pubmed identfication
  • 1673147
• RefSeq identity
  • NM_000882
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000158942

Gene info

• Identity
  HGNC:8053
• Gene
  NUDT6
• Long gene name
  nudix hydrolase 6
• Synonyms gene name
  • nudix (nucleoside diphosphate linked moiety X)-type motif 6
• Synonyms
  • gfg-1
  • gfg
  • FGF2AS
  • FGF-AS
• GenBank acession
  • AF019632
• Locus
  4q28.1
• Discovery year
  1999-09-03
• Entrez gene record
  11162
• Pubmed identfication
  • 7984147
  • 10022609
• RefSeq identity
  • NM_007083
• Classification
  • Nudix hydrolase family
• VEGA ID
  OTTHUMG00000039507

Gene info

• Identity
  HGNC:3682
• Gene
  FGF4
• Long gene name
  fibroblast growth factor 4
• Synonyms gene
  • HSTF1
• Synonyms gene name
  • heparin secretory transforming protein 1
• Synonyms
  • K-FGF
  • HBGF-4
  • HST
  • HST-1
  • KFGF
• Synonyms name
  • human stomach cancer, transforming factor from FGF-related oncogene
  • kaposi sarcoma oncogene
  • transforming protein KS3
• GenBank acession
  • M17446
• Locus
  11q13.3
• Discovery year
  1988-04-20
• Entrez gene record
  2249
• Pubmed identfication
  • 1611909
• RefSeq identity
  • NM_002007
• Classification
  • Fibroblast growth factor family
  • Receptor ligands
• VEGA ID
  OTTHUMG00000167887

Gene info

• Identity
  HGNC:3665
• Gene
  FGF1
• Long gene name
  fibroblast growth factor 1
• Synonyms gene
  • FGFA
• Synonyms gene name
  • fibroblast growth factor 1 (acidic)
• Synonyms
  • AFGF
  • ECGF
  • ECGFA
  • ECGFB
  • HBGF1
  • ECGF-beta
  • FGF-alpha
  • GLIO703
• Synonyms name
  • heparin-binding growth factor 1
  • endothelial cell growth factor, alpha
  • endothelial cell growth factor, beta
• GenBank acession
  • X59065
• Locus
  5q31.3
• Discovery year
  1986-01-01
• Entrez gene record
  2246
• Pubmed identfication
  • 1697263
  • 3523756
• RefSeq identity
  • NM_000800
• Classification
  • Fibroblast growth factor family
  • Receptor ligands
• VEGA ID
  OTTHUMG00000059703

MeSH Data

• Name
  Tumor Stem Cell Assay
• Concept
  Scope note: A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
• Tree numbers
  • E01.370.225.500.383.910
  • E01.370.225.500.388.930
  • E05.200.500.383.910
  • E05.200.500.388.930
  • E05.242.383.910
  • E05.242.417.500
  • E05.337.550.200.800
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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