Antibiotic. Fatty acid synthase (FAS) inhibitor, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase, thus inhibiting protein acylation. Produces metabolic effects similar to effects of leptin, but through mechanisms that are independent of, or downstream from, both leptin and melanocortin receptors. Apoptosis inducer. Inhibitor of bacterial fatty acid synthesis (inhibits FabH, FabB and FabF condensation enzymes).
White to off-white solid
Is this a salt?
Is it cell-permeable?
DMSO (20 mg/ml) or EtOH (20 mg/ml)
Maximum time for storage
Protect from light and air
For cells, cell lines and tissues in culture till half confluency.
Cerulenin for activation
Cerulenin to measure cellular activation