Afuresertib hydrochloride

Alternative_name

N-[(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide, monohydrochloride
Description

Afuresertib is a potent and selective Akt inhibitor with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis.
CAS Number

1047645-82-8
Structure Available

Yes
Molecular Formula

C₁₈H₁₇Cl₂FN₄OS • HCl
Molecular Weight

463.8
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO >30 mg/ml)
Handling

Protect from air and light
Tag Line

A potent and selective Akt inhibitor
Storage Condition

-20°C
Shipping Condition

Gel Pack
Shelf Life

36 months
PubChem CID

46843056
PubChem CID Link
SMILES

CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
InChi

InChI=1S/C18H17Cl2FN4OS.ClH/c1-25-16(14(19)9-23-25)13-7-15(27-17(13)20)18(26)24-12(8-22)6-10-3-2-4-11(21)5-10;/h2-5,7,9,12H,6,8,22H2,1H3,(H,24,26);1H/t12-;/m0./s1
InChi Key

YFQJOPFTGMHYNV-YDALLXLXSA-N
Data Sheet Link
MSDS Available

Yes