Microcystin-LR

Alternative_name

Cyanoginosin-LR
Description

A hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less sensitive to PP2B and does not inhibit PP2C up to 4 µM.
CAS Number

101043-37-2
Structure Available

Yes
Salt Form

No
Molecular Formula

C₄₉H₇₄N₁₀O₁₂
Molecular Weight

995.17
Cell Permeable

No
Purity

≥95% by HPLC
Solubilities

DMSO or EtOH or MeOH
Handling

Protect from air and moisture
Tag Line

A protein phosphatase 1 (PP1) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
MDL Number

MFCD01774058
PubChem CID

445434
PubChem CID Link
SMILES

CC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
InChi

InChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
InChi Key

ZYZCGGRZINLQBL-GWRQVWKTSA-N
Data Sheet Link
MSDS Available

Yes

Identity

HGNC:11910
Gene

TNFRSF25
Long gene name

TNF receptor superfamily member 25
Synonyms gene
- TNFRSF12
Synonyms gene name
- tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- tumor necrosis factor receptor superfamily, member 25
Synonyms
- DR3
- TRAMP
- WSL-1
- LARD
- WSL-LR
- DDR3
- TR3
- APO-3
GenBank acession
- U72763
Locus

1p36.31
Discovery year

1998-12-04
Entrez gene record

8718
Pubmed identfication
- 9052839
- 8934525
RefSeq identity
- NM_148965
Classification
- Tumor necrosis factor receptor superfamily
VEGA ID

OTTHUMG00000000831