Microcystin-LR
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Catalog number1840-100
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PricePlease ask
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Size100 ug
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Alternative_nameCyanoginosin-LR
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DescriptionA hepatotoxic cyclic heptapeptide toxin produced by cyanobacteria. A selective inhibitor of protein phosphatase 1 (PP1) (IC₅₀ = 1.7 nM) and protein phosphatase 2A (PP2A) (IC₅₀ = 0.04 nM). Less sensitive to PP2B and does not inhibit PP2C up to 4 µM.
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CAS Number101043-37-2
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₄₉H₇₄N₁₀O₁₂
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Molecular Weight995.17
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Cell PermeableNo
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Purity≥95% by HPLC
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SolubilitiesDMSO or EtOH or MeOH
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HandlingProtect from air and moisture
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Tag LineA protein phosphatase 1 (PP1) inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD01774058
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PubChem CID445434
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SMILESCC1C(NC(=O)C(NC(=O)C(C(NC(=O)C(NC(=O)C(NC(=O)C(=C)N(C(=O)CCC(NC1=O)C(=O)O)C)C)CC(C)C)C(=O)O)C)CCCN=C(N)N)C=CC(=CC(C)C(CC2=CC=CC=C2)OC)C
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InChiInChI=1S/C49H74N10O12/c1-26(2)23-37-46(66)58-40(48(69)70)30(6)42(62)55-35(17-14-22-52-49(50)51)45(65)54-34(19-18-27(3)24-28(4)38(71-10)25-33-15-12-11-13-16-33)29(5)41(61)56-36(47(67)68)20-21-39(60)59(9)32(8)44(64)53-31(7)43(63)57-37/h11-13,15-16,18-19,24,26,28-31,34-38,40H,8,14,17,20-23,25H2,1-7,9-10H3,(H,53,64)(H,54,65)(H,55,62)(H,56,61)(H,57,63)(H,58,66)(H,67,68)(H,69,70)(H4,50,51,52)/b19-18+,27-24+/t28-,29-,30-,31+,34-,35-,36+,37-,38-,40+/m0/s1
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InChi KeyZYZCGGRZINLQBL-GWRQVWKTSA-N
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MSDS AvailableYes
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Gene target
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Gene symbolTNFRSF25
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Short nameMicrocystin-LR
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Alternative nameMicrocystin-LR
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Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 25
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)
- tumor necrosis factor receptor superfamily, member 25
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-12-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
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VEGA ID