Andrographolide, Apoptosis Inducer
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Catalog number
SIH-220-500MG
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Price
Please ask
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Size
500 mg
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Stock availabilitIn Stock
In Stock
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CAS number
5508-58-7
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Description
Apoptosis Inducer
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Molecular weight
350,45 g/mol
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Primary research fields
Cancer, Apoptosis
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Other name
(3E)-4-Hydroxy-3-{2-[(1R,4aS,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydro-1-naphthalenyl]ethylidene}dihydro-2(3H)-furanone
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Product category
Small Molecules
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Product type
Inducer
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Chemical formula
C20H30O5
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
DMSO
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Physical appearance
Off-white Solid
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Storage recommendations
-20ÂșC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution: Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S24/25 - Avoid contact with skin and eyes S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection
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PubChem number
5318517
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Scientific context
Andrographolide is a labdane diterpenoid that is the main bioactive component of the medicinal plant Andrographis paniculata. Is has been shown to be effective against certain cancers, and is an effective purgative (1). It blocks T-cell proliferation to allogenic stimuli and the chemotactic migration of macrophages induced by complement (2, 3).
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Bibliography
1. Chakravarti R.N., Chakravarti D. (1951) Ind. Med Gaz. 86(3): 96-7. 2. Tsai H.R., et al. (2004) Eur J Pharmacol. 498: 45-52. 3. Rajagopal S., et al. (2003) J Exp. Ther. Oncol. 3: 147-158.
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Release date
8-Apr-2011
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Andrographolide (SIH-220), a Induces mitochondrial -mediated apoptosis in lymphoma cells. CAS #: 5508-58-7. Molecular Formula: C20H30O5. Molecular Weight: 350.45 g/mol. Chemical structure of Andrographolide, a Induces mitochondrial -mediated apoptosis in lymphoma cells (SIH-220). CAS # 5508-58-7. Molecular Formula: C20H30O5.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.5
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Additional description
This 1 is suited for programmed cell-death studies.
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Gene target
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Short name
Andrographolide, Apoptosis Inducer
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Technique
apoptosis, apoptosis pathway
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Alternative name
Andrographolide, programmed cellular destruction Inducer
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Alternative technique
celldeath
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