Anti-CNG channel beta 1/truncated GARP, ALEXA Fluor 594

• Catalog number
  GENTObs-11332R-A594
• Price
  Please ask
• Size
  100 microliters

• Type
  Conjugated Primary Antibody
• Conjugated with
  ALEXA FLUOR® 594
• Host organism
  Rabbit (Oryctolagus cuniculus)
• Target Protein Peptide
  CNG channel beta 1/truncated GARP
• Specificity
  This antibody reacts specifically with CNG channel beta 1/truncated GARP
• Modification
  No modification has been applied to this antibody
• Modification site
  None
• Clonality
  Polyclonal Antibody
• Clone
  Polyclonal Antibodies
• Concentration
  1ug per 1ul
• Subcellular locations
  Extracellular
• Antigen Source
  KLH conjugated synthetic peptide derived from human truncated GARP
• Gene ID
  N/A
• Swiss Prot
  N/A
• Applications
  FCM, IF(IHC-P)
• Applications with corresponding dilutions
  FCM(1:20-100), IF(IHC-P)(1:50-200)
• Cross reactive species
  Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
• Cross Reactive Species details
  No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
• Background information
  Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
• Purification method
  Purified by Protein A.
• Storage
  Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
• Excitation emission
  590nm/617nm
• Synonyms
  CNCG 4; CNCG2; CNCG3L; CNCG4; CNG 4; CNG channel 4; CNG channel beta 1; CNG4; CNGB 1; CNGB1; CNGB1B; Cyclic nucleotide gated cation channel 4; Cyclic nucleotide gated cation channel; Cyclic nucleotide gated cation channel beta 1; Cyclic nucleotide gated cation channel gamma; Cyclic nucleotide gated cation channel modulatory subunit; Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like; Cyclic nucleotide gated channel beta 1; GAR1; GARP; GARP2; Glutamic acid rich protein; RCNC2; RCNCb; RCNCbeta; RP45; 240 kDa protein of rod photoreceptor CNG channel; cGMP gated cation channel beta subunit; Truncated glutamic acid rich protein; Truncated rod photoreceptor cGMP gated channel beta subunit; Truncated rod photoreceptor cGMP-gated channel beta-subunit; CNGB1_HUMAN.
• Also known as
  CNG channel beta 1/truncated GARP Antibody
• Other name
  Anti-CNG channel beta 1/truncated GARP
• Advisory
  Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
• Properties
  For facs or microscopy Alexa 1 conjugate.
• Conjugation
  Alexa Fluor, ALEXA FLUOR® 594
• Conjugated
  Alexa conjugate 1
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.

• Gene target
  CNG   channel   beta   1/truncated   GARP  
• Gene symbol
  SH3BGR, LRRC32, CNGB1
• Short name
  Anti-CNG channel beta 1/truncated GARP
• Technique
  anti-, anti, antibody to, antibodies
• Isotype
  Immunoglobulin G (IgG)
• Label
  ALEXA FLUOR 594
• Alternative name
  CNG channel beta 1/truncated GARP Antibody, ALEXA FLUOR® 594 Conjugated
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:10822
• Gene
  SH3BGR
• Long gene name
  SH3 domain binding glutamate rich protein
• Synonyms gene name
  • SH3 domain binding glutamic acid-rich protein
  • SH3 domain binding glutamate-rich protein
• Synonyms
  • 21-GARP
• Synonyms name
  • 21-glutamic acid-rich protein
• Locus
  21q22.2
• Discovery year
  1996-10-11
• Entrez gene record
  6450
• Pubmed identfication
  • 9050928
• RefSeq identity
  • NM_007341
• Classification
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000074113

Gene info

• Identity
  HGNC:4161
• Gene
  LRRC32
• Long gene name
  leucine rich repeat containing 32
• Synonyms gene
  • D11S833E
  • GARP
• Synonyms gene name
  • glycoprotein A repetitions predominant
• GenBank acession
  • Z24680
• Locus
  11q13.5
• Discovery year
  1994-12-15
• Entrez gene record
  2615
• Pubmed identfication
  • 8180135
  • 1543912
• RefSeq identity
  • NM_005512
• VEGA ID
  OTTHUMG00000133687

Gene info

• Identity
  HGNC:2151
• Gene
  CNGB1
• Long gene name
  cyclic nucleotide gated channel subunit beta 1
• Synonyms gene
  • CNCG2
  • CNCG3L
• Synonyms gene name
  • cyclic nucleotide gated channel beta 1
• Synonyms
  • RCNC2
  • RCNCb
  • GARP
  • GAR1
  • CNGB1B
  • RP45
• Synonyms name
  • glutamic acid-rich protein
  • cyclic nucleotide-gated cation channel beta-1
• GenBank acession
  • AF042498
• Locus
  16q21
• Discovery year
  1994-12-20
• Entrez gene record
  1258
• Pubmed identfication
  • 8766832
  • 7590744
  • 16382102
• RefSeq identity
  • NM_001297
• Classification
  • Cyclic nucleotide gated channels
• VEGA ID
  OTTHUMG00000154810

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

Product files

Similar products