TGFBR2 Antibody

• Catalog number
  R30965
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  TGFBR2
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB
• Recommended dilutions
  Western blot: 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the TGFBR2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This TGFBR2 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P37173
• Purity
  Antigen affinity
• Description
  Transforming growth factor, beta receptor II, also known as TGFBR2 and TGFR-2, is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. A TGFBR2 cDNA encoding a deduced 565-amino acid protein with a calculated molecular mass of approximately 60 kD in length. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated withMarfan syndrome,Loeys-Deitz aortic aneurysm syndrome,Osler-Weber-Rendu syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. TGFBR2 may be a target of the EWS-FLI1 fusion protein found in Ewing sarcoma and related peripheral primitive neuroectodermal tumors.
• Immunogen
  An amino acid sequence from the middle region of human TGF beta Receptor II (KGNLQEYLTRHVISWED) was used as the immunogen for this TGFBR2 antibody (100% homologous in human, mouse and rat).
• Storage
  After reconstitution, the TGFBR2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  TGFBR2  
• Gene symbol
  TGFBR2
• Short name
  Anti-TGFBR2
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to TGFBR2
• Alternative technique
  antibodies
• Alternative to gene target
  transforming growth factor, beta receptor II (70/80kDa), AAT3 and FAA3 and LDS1B and LDS2 and LDS2B and MFS2 and RIIC and TAAD2 and TGFbeta-RII and TGFR-2, TGFBR2 and IDBG-23359 and ENSG00000163513 and 7048, transforming growth factor beta receptor activity, Cell surfaces, Tgfbr2 and IDBG-203902 and ENSMUSG00000032440 and 21813, BT.66001 and IDBG-644071 and ENSBTAG00000019832 and 535376

Gene info

• Identity
  HGNC:11773
• Gene
  TGFBR2
• Long gene name
  transforming growth factor beta receptor 2
• Synonyms gene
  • MFS2
• Synonyms gene name
  • transforming growth factor, beta receptor II (70/80kDa)
  • transforming growth factor beta receptor II
• Synonyms
  • TBRII
  • TBR-ii
• Locus
  3p24.1
• Discovery year
  1993-09-30
• Entrez gene record
  7048
• Pubmed identfication
  • 1319842
  • 15235604
• Classification
  • Type 2 receptor serine/threonine kinases
• VEGA ID
  OTTHUMG00000130569
• Locus Specific Databases
  • LOVD - Center for Medical Genetics, Ghent, Belgium
  • The TGFBR2 mutations database
  • LRG_779

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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