IL-33

  • Catalog number
    E21-G73
  • Price
    Please ask
  • Size
    10ug
  • Shipping_Temperature
    Ambient
  • Product_State
    Lyophilized
  • Formulation_Description
    Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
  • Storage
    Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Reconstitution
    Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in ddH2O.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Purity
    Greater than 95% as determined by reducing SDS-PAGE.
  • Endotoxin
    Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
  • Background
    Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
  • Alternative Names
    Interleukin 33; IL-33; IL33; C9orf26; NKHEV; Interleukin-1 family member 11; DVS27; NF-HEV and IL- 1F11
  • Expression system
    E.coli
  • Gene target
    IL-33  
  • Gene symbol
    IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C, IL17D, IL17A, IL23A
  • Short name
    IL-33
  • Species
    Mouse
  • Alternative name
    Interleukin-33
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
Gene info
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