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anti-NQO1 Antibody

anti-NQO1 Antibody is available 1 time from Biovision labs

3639-100 | anti-NQO1 Antibody size: NQO1 Antibody | 417.68 USD

Catalog number 3639-100
Supplier Biovision
Price 417.68 USD
Size NQO1 Antibody
1. Gene info
Identity 2874
Gene NQO1
Long gene name NAD(P)H quinone dehydrogenase 1
Synonyms gene
  • NMOR1
  • DIA4
Synonyms gene name
  • diaphorase (NADH/NADPH) (cytochrome b-5 reductase)
  • NAD(P)H dehydrogenase, quinone 1
Synonyms
  • DHQU
  • QR1
  • DTD
GenBank acession
  • M81600
Locus 16q22.1
Discovery year 2001-06-22
Entrez gene record 1728
Pubmed identfication
  • 2843525
Havana BLAST/BLAT OTTHUMG00000137575
Product images
    #0#.jpeg
Target of this antibody: NQO1
Alternative names of antibody target: Azoreductase, DT-diaphorase, Menadione reductase, NAD (P) H, quinine oxidoreductase 1
Background information: NAD (P) H:quinone oxidoreductase 1 (NQO1) and NRH:quinone oxidoreductase (NQO2) are flavoproteins that catalyze the metabolic detoxification of quinones and their derivatives to hydroquinones, using either NADH or NADPH as the electron donor. This protects cells against quinone-induced oxidative stress, cytotoxicity, and mutagenicity. Many tumors overexpress NQO1, which is an obligate two-electron reductase that deactivates toxins and activates bioreductive anticancer drugs. NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals and radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression and coordinated induction of NQO1. ARE activation by tert-butylhydroquinone is dependent on PI3-kinase, which lies upstream of Nrf2. Nrf2, c-Jun, Nrf1, Jun-B and Jun-D bind to the ARE and regulate expression and induction of NQO1 gene. Maf-Maf homodimers and possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE and do not repress NQO1 transcription.
Antibody host: Rabbit
Clonality of antibody: Polyclonal
Isotype: Rabbit IgG
This antibody reacts with: Human, mouse, rat
Immunogene sequence: Synthetic peptide at C-terminal
Concentration of antibody: 0.5 mg/ml
Form of antibody: Liquid
Formulation of this antibody: 100 µg (0.5 mg/ml) of antibody in PBS, 0.01 % BSA, 0.01 % thimerosal, and 50 % glycerol, pH 7.2
Purification method: Affinity purified
This antibody has been succesfully tested for use in following methods: Western blot
Recommended usage: Western blot: 1:200
Storage information: Shelf time: 12 months in temp.: -20 deg.C
Shipping conditions: gel pack
How to handle this antibody: The antibody solution should be gently mixed before use.
Description This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
Properties If you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
French translation anticorps
Gene targetNQO1
Short name anti-NQO1 Antibody
Technique Antibody, anti
Alternative name antibody to-Nicotinamide adenine dinucleotide(P)H dehydrogenase, quinone 1 (Antibody to)
Alternative technique antibodies
Alternative to gene target NAD(P)H dehydrogenase, quinone 1, DHQU and DIA4 and DTD and NMOR1 and NMORI and QR1, NQO1 and IDBG-39427 and ENSG00000181019 and 1728, cytochrome-b5 reductase activity, Cytoplasm, Nqo1 and IDBG-190808 and ENSMUSG00000003849 and 18104, NQO1 and IDBG-634590 and ENSBTAG00000020632 and 519632
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anti-NQO1 Antibody | Technique alternative | 01012192661
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