JMJD6 Antibody
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Catalog number6109-50
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PricePlease ask
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Size50 μg
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Antibody TargetJMJD6
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Target Alternative NameJumonji Domain Containing 6; PTDSR
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Antibody TypePolyclonal
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Species ReactivitiesHuman, chimpanzee, bovine, canine, equine, mouse, opossum
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Immunogen SequenceHuman recombinant JMJD2A aa 127-144
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AccessionQ6NYC1
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Gene Id23210
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AppearanceColorless liquid
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FormLiquid
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Formulation50 µg of antibody in 100 µl PBS containing 0.05% BSA and 0.05% sodium salt.
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PurificationAntigen affinity purified
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ApplicationWestern blot
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Positive ControlWestern blot: Human brain lysate, mouse brain lysate
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Application And UsagesWestern blot: 0.25-1.0 µg/ml. However, the optimal conditions should be determined individually.
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DescriptionTudor domains are small protein structural motifs of about ~50 amino acids related to the “royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification, and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. JMJD6 is a 403 amino acid nuclear protein lysyl-hydroxylase that has been reported to have arginine demethylase activity for histone H3 at ‘Arg-2’ and histone H4 at ‘Arg-3’. JMJD6 has been sμggested to function in the differentiation of multiple organs during embryogenesis and regulate hematopoietic differentiation and macrophage cytokine responses. First identified as a putative phosphatidylserine receptor involved in phagocytosis of apoptotic cells, JMJD6 was later indicated not to directly function in the clearance of apoptotic cells. It is ubiquitously expressed in most tissues and is upregulated in patients with chronic pancreatitis and upon cytokine treatment, but not upon TNF-α treatment.
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Storage Condition-20 °C
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Shipping Conditiongel pack
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Shelf Life12 months
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UsageFor Research Use Only! Not to be used in humans.
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HandlingThe antibody solution should be gently mixed before use.
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Western Blot VerifiedVerified
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Immunocytochemistry VerifiedNot Verified
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Immunofluorescence VerifiedNot Verified
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Immunoprecipitation VerifiedNot Verified
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ELISA VerifiedNot Verified
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ChIP VerifiedNot Verified
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Flow Cytometry VerifiedNot Verified
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PropertiesIf you buy Antibodies supplied by Biovision they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translationanticorps
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Gene target
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Gene symbolJMJD6
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Short nameJMJD6 Antibody
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative namejumonji domain containing 6 (antibody to-)
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Alternative techniqueantibodies
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Alternative to gene targetjumonji domain containing 6, PSR and PTDSR and PTDSR1, JMJD6 and IDBG-70010 and ENSG00000070495 and 23210, peptidyl-lysine 5-dioxygenase activity, nuclei, Jmjd6 and IDBG-214522 and ENSMUSG00000056962 and 107817, JMJD6 and IDBG-643020 and ENSBTAG00000019153 and 508343
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Gene info
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Identity
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Gene
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Long gene namejumonji domain containing 6, arginine demethylase and lysine hydroxylase
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Synonyms gene
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Synonyms gene name
- phosphatidylserine receptor
- jumonji domain containing 6
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Synonyms
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GenBank acession
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Locus
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Discovery year2002-10-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Iron (II) and 2-oxoglutarate dependent oxygenases
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VEGA ID
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data