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Stock availabilitIn Stock
In Stock
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CAS number
935693-62-2
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Description
HMT inhibitor
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Molecular weight
600,02 g/mol
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Primary research fields
Cell Signaling, Epigenetics, Cancer
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Other name
2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C28H38N6O2*3HCl
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Origin
Synthetic
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Purity pourcentage
>98%
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Soluble in
May be dissolved in DMSO (100 mM) or Water (100 mM)
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Physical appearance
Cream solid
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
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PubChem number
25150857
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Scientific context
G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
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Bibliography
1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.
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Release date
11-Apr-2013
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of BIX-01294 (SIH-347), a Histone methyltransferase inhibitor. CAS #: 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl. Molecular Weight: 600.02 g/mol. Chemical structure of BIX-01294, a Histone methyltransferase inhibitor (SIH-347). CAS # 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.005
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.