BIX-01294, HMT inhibitor

  • Catalog number
    SIH-347-25MG
  • Price
    Please ask
  • Size
    25 mg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    935693-62-2
  • Description
    HMT inhibitor
  • Molecular weight
    600,02 g/mol
  • Primary research fields
    Cell Signaling, Epigenetics, Cancer
  • Other name
    2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-4-quinazolinamine trihydrochloride
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C28H38N6O2*3HCl
  • Origin
    Synthetic
  • Purity pourcentage
    >98%
  • Soluble in
    May be dissolved in DMSO (100 mM) or Water (100 mM)
  • Physical appearance
    Cream solid
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: Caution – Substance not yet fully tested. Safety Phrases: S22 - Do not breathe dust S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection S24/25- Avoid contact with skin and eyes
  • PubChem number
    25150857
  • Scientific context
    G9a-like protein and G9a histone lysine methyltransferase inhibitor (IC values are 0.7 and 1.7 µM respectively) that displays no activity at other histone methyltransferases up to 37 µM. Modulates H3K9me2 levels in mammalian cells and potentiates induction of pluripotent stem cells from somatic cells in vitro.
  • Bibliography
    1. Kubicek S., et al. (2007) Mol Cell. 25(3): 473-481. 2. Shi Y., et al. (2008) Cell Stem Cell. 3(5): 568-574. 3. Chang Y., et al. (2009) Nat Struct Mol Biol. 16(3): 312-317.
  • Release date
    11-Apr-2013
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of BIX-01294 (SIH-347), a Histone methyltransferase inhibitor. CAS #: 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl. Molecular Weight: 600.02 g/mol. Chemical structure of BIX-01294, a Histone methyltransferase inhibitor (SIH-347). CAS # 935693-62-2. Molecular Formula: C28H38N6O2 * 3HCl.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.025
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Gene symbol
    ALG1
  • Short name
    BIX-01294, HMT inhibitor
  • Alternative name
    BIX-01294, HMT suppressor
Gene info
  • Identity
  • Gene
  • Long gene name
    ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
  • Synonyms gene name
    • asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase)
    • asparagine-linked glycosylation 1, beta-1,4-mannosyltransferase homolog (S. cerevisiae)
    • ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    2003-10-15
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Glycosyl transferases group 1 domain containing
  • VEGA ID
  • Locus Specific Databases
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