CH-223191

• Catalog number
  2723-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  1-Methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl-1H-pyrazole-5-carboxamide
• Description
  CH-223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist. It blocks activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (IC₅₀ = 0.03 µM). It also blocks TCDD-mediated translocation and DNA-binding activity of the AhR. Displays no AhR agonist activity (at concentrations up to 100 μM). Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes.
• CAS Number
  301326-22-7
• Structure Available
  Y
• Salt Form
  No
• Molecular Formula
  C₁₉H₁₉N₅O
• Molecular Weight
  333.39
• Cell Permeable
  Yes
• Purity
  ³95%
• Solubilities
  DMSO (>30 mg/ml) or EtOH (~3 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A potent and specific aryl hydrocarbon receptor (AhR) antagonist.
• Storage Condition
  -20°C
• Shipping Condition
  Gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00377884
• PubChem CID
  3091786
• PubChem CID Link
• SMILES
  CC1=CC=CC=C1N=NC2=CC(=C(C=C2)NC(=O)C3=CC=NN3C)C
• InChi
  InChI=1S/C19H19N5O/c1-13-6-4-5-7-17(13)23-22-15-8-9-16(14(2)12-15)21-19(25)18-10-11-20-24(18)3/h4-12H,1-3H3,(H,21,25)
• InChi Key
  LKTNEXPODAWWFM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  CH-223191  
• Gene symbol
  CKAP5, C4B
• Short name
  CH-223191
• Alternative name
  CH-223191

Gene info

• Identity
  HGNC:28959
• Gene
  CKAP5
• Long gene name
  cytoskeleton associated protein 5
• Synonyms
  • ch-TOG
  • KIAA0097
  • TOG
  • TOGp
• Locus
  11p11.2
• Discovery year
  2005-06-01
• Entrez gene record
  9793
• Pubmed identfication
  • 7788527
  • 8536682
• RefSeq identity
  • NM_014756
• Classification
  • Small nucleolar RNA protein coding host genes
  • MicroRNA protein coding host genes
  • TOG domain containing
• VEGA ID
  OTTHUMG00000166599

Gene info

• Identity
  HGNC:1324
• Gene
  C4B
• Long gene name
  complement C4B (Chido blood group)
• Synonyms gene name
  • complement component 4B
  • complement component 4B (Chido blood group)
• Synonyms
  • CPAMD3
  • C4F
  • CO4
  • C4B1
  • C4B3
  • CH
• GenBank acession
  • AF019413
• Locus
  6p21.33
• Discovery year
  2001-06-22
• Entrez gene record
  721
• RefSeq identity
  • NM_001002029
• Classification
  • C3 and PZP like, alpha-2-macroglobulin domain containing
  • Blood group antigens
  • Complement system activation components
• VEGA ID
  OTTHUMG00000031187
• Locus Specific Databases
  • LRG_138

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