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Synonyms
IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1
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Alternative_names
IL13RA1, CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1
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Description
Shown to bind tyrosine kinase TYK2 to mediate various signaling processes.
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Recombinant
Yes
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Source
HEK293 cells
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Purity by SDS PAGE
≥98%
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Assay
SDS-PAGE
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Biological activity
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 ug/mL (100 uL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
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Results
Measured by its binding ability in a functional ELISA. Immobilized rhIL13Ra1 at 2 ug/mL (100 uL/well) can bind rhIL13 with a linear range of 0.1-10 ng/mL.
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Molecular Weight
This protein is fused with a 6×his tag at the C-terminus and the protein has a calculated MW of 38 kDa. DTT-reduced protein migrates as 55-65 kDa in SDS-PAGE due to glycosylation.
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized
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Physical form description
Lyophilized from 0.22 um filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
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Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
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Background Information
Interleukin 13 receptor, alpha 1, also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
IL13RA1
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Short name
CellExp™ IL13RA1/CD213A1, recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Humans
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Alternative name
H. sapiens CellExp™ interleukin 13 receptor, a 1/CD213A1, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
interleukin 13 receptor, alpha 1, CD213A1 and IL-13Ra and NR4, IL13RA1 and IDBG-83434 and ENSG00000131724 and 3597, interleukin-13 receptor activity, Plasma membranes, Il13ra1 and IDBG-137900 and ENSMUSG00000017057 and 16164, IL13RA1 and IDBG-629527 and ENSBTAG00000019338 and 407110
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