BAY 41-2272

• Catalog number
  9429-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
• Description
  BAY 41-2272 is a soluble guanylyl cyclase (sGC) activator; acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit. Inhibits platelet aggregation (IC₅₀ = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC₅₀ = 0.30 μM). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.
• CAS Number
  256376-24-6
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₇FN₆
• Molecular Weight
  360.39
• Cell Permeable
  Yes
• Purity
  ≥98%
• Solubilities
  DMSO (>35 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A soluble guanylyl cyclase (sGC) activator
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD06411391
• PubChem CID
  9798973
• PubChem CID Link
• SMILES
  C1CC1C2=CN=C(N=C2N)C3=NN(C4=C3C=CC=N4)CC5=CC=CC=C5F
• InChi
  InChI=1S/C20H17FN6/c21-16-6-2-1-4-13(16)11-27-20-14(5-3-9-23-20)17(26-27)19-24-10-15(12-7-8-12)18(22)25-19/h1-6,9-10,12H,7-8,11H2,(H2,22,24,25)
• InChi Key
  ATOAHNRJAXSBOR-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAY   41-2272  
• Gene symbol
  SNORD115-41, IGHV3-41, IGLVVII-41-1, IGKV6D-41, IGLV1-41, CCDC18, RNU6-41P, TRIM71, METTL25B, CCDC34
• Short name
  BAY 41-2272
• Alternative name
  BAY 41-2272

Gene info

• Identity
  HGNC:33060
• Gene
  SNORD115-41
• Long gene name
  small nucleolar RNA, C/D box 115-41
• Synonyms
  • HBII-52-41
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033815
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003356.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5602
• Gene
  IGHV3-41
• Long gene name
  immunoglobulin heavy variable 3-41 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-41
  • immunoglobulin heavy variable 3-41 pseudogene
• GenBank acession
  • M99670
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28428
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152089

Gene info

• Identity
  HGNC:15691
• Gene
  IGLVVII-41-1
• Long gene name
  immunoglobulin lambda variable (VII)-41-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (VII)-41-1
  • immunoglobulin lambda variable (VII)-41-1 pseudogene
• Synonyms
  • IGLV(VII)-41-1
• GenBank acession
  • X99568
• Locus
  22q11.22
• Discovery year
  2001-05-15
• Entrez gene record
  84089
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151296

Gene info

• Identity
  HGNC:5838
• Gene
  IGKV6D-41
• Long gene name
  immunoglobulin kappa variable 6D-41 (non-functional)
• Synonyms gene name
  • immunoglobulin kappa variable 6D-41
• GenBank acession
  • X12688
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28869
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151621

Gene info

• Identity
  HGNC:5878
• Gene
  IGLV1-41
• Long gene name
  immunoglobulin lambda variable 1-41 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable 1-41
  • immunoglobulin lambda variable 1-41 pseudogene
• GenBank acession
  • M94118
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28824
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151056

Gene info

• Identity
  HGNC:30370
• Gene
  CCDC18
• Long gene name
  coiled-coil domain containing 18
• Synonyms
  • NY-SAR-41
• Locus
  1p22.1
• Discovery year
  2005-06-24
• Entrez gene record
  343099
• Pubmed identfication
  • 12601173
• RefSeq identity
  • NM_206886
• VEGA ID
  OTTHUMG00000010598

Gene info

• Identity
  HGNC:34247
• Gene
  RNU6-41P
• Long gene name
  RNA, U6 small nuclear 41, pseudogene
• Synonyms gene
  • RNU6-41
• Synonyms gene name
  • RNA, U6 small nuclear 41
• Locus
  1q25.3
• Discovery year
  2008-06-10
• Entrez gene record
  106478912

Gene info

• Identity
  HGNC:32669
• Gene
  TRIM71
• Long gene name
  tripartite motif containing 71
• Synonyms gene name
  • tripartite motif containing 71, E3 ubiquitin protein ligase
• Synonyms
  • LIN41
  • LIN-41
• Locus
  3p22.3
• Discovery year
  2006-03-30
• Entrez gene record
  131405
• RefSeq identity
  • NM_001039111
• Classification
  • Ring finger proteins
  • Tripartite motif containing
• VEGA ID
  OTTHUMG00000155778

Gene info

• Identity
  HGNC:24273
• Gene
  METTL25B
• Long gene name
  methyltransferase like 25B
• Synonyms gene
  • C1orf66
  • RRNAD1
• Synonyms gene name
  • chromosome 1 open reading frame 66
  • ribosomal RNA adenine dimethylase domain containing 1
• Synonyms
  • CGI-41
• GenBank acession
  • BC011382
• Locus
  1q23.1
• Discovery year
  2005-05-17
• Entrez gene record
  51093
• Pubmed identfication
  • 10810093
  • 310876
• RefSeq identity
  • NM_015997
• Classification
  • 7BS orphan methyltransferases
• VEGA ID
  OTTHUMG00000041302

Gene info

• Identity
  HGNC:25079
• Gene
  CCDC34
• Long gene name
  coiled-coil domain containing 34
• Synonyms
  • NY-REN-41
  • L15
  • RAMA3
• GenBank acession
  • AF382034
• Locus
  11p14.1
• Discovery year
  2005-10-28
• Entrez gene record
  91057
• Pubmed identfication
  • 11173847
• RefSeq identity
  • NM_030771
• VEGA ID
  OTTHUMG00000166211

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