GSK-484 hydrochloride

Alternative_name

((3S,4R)-3-Amino-4-hydroxypiperidin-1-yl)(2-(1-(cyclopropylmethyl)-1H-indol-2-yl)-7-methoxy-1-methyl-1H-benzo[d]imidazol-5-yl)methanone hydrochloride
Description

GSK-484 is a potent and reversible inhibitor of PAD4 (Protein Arginine Deiminase 4) (IC₅₀ = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK-484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils.
CAS Number

1652591-81-5
Structure Available

Yes
Salt Form

No
Molecular Formula

C₂₇H₃₂ClN₅O₃
Molecular Weight

510.03
Cell Permeable

Yes
Purity

≥98%
Solubilities

DMSO (~30 mg/ml)
Handling

Protect from air and moisture
Tag Line

A potent protein arginine deiminase 4 (PAD4) inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

36 months
PubChem CID

86340151
PubChem CID Link
SMILES

CN1C2=C(C=C(C=C2OC)C(=O)N3CCC(C(C3)N)O)N=C1C4=CC5=CC=CC=C5N4CC6CC6.Cl
InChi

InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChi Key

MULKOGJHUZTANI-ADMBKAPUSA-N
Data Sheet Link
MSDS Available

Yes