CD271 / NGFR monoclonal antibody

• Catalog number
  1A-642-T100
• Price
  Please ask
• Size
  100 assays

• Long name
  Mouse Monoclonal Antibody against Human CD271 / NGFR, Clone: NGFR5
• Antigen
  CD271
• Species reactivity
  Human (Homo sapiens), Non-Human (Homo sapiens) Primates, Feline (Cat), Rabbit, Ferret
• Negative species reactivity
  Mouse, Rat
• Clonality
  Monoclonal Antibody (Mab)
• Clone
  NGFR5
• Applications
  FC, IP, WB, IHC(P), ICC, MC
• Immunogen
  Purified CD271 protein isolated from human melanoma cell line A875
• Format conjugation
  APC
• Specificity
  The mouse monoclonal antibody NGFR5 (originally C34C) recognizes CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily. The epitope is localized within ammino acids 1 - 160.
• Research area
  Neurobiology (Veterinary), Neurobiology (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
• Storage buffer
  The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
• Shipping and storage
  Mouse Monoclonal Antibody against Human CD271 / NGFR, Clone: NGFR5 is transported on blue ice/ice packs and should be stored at temperatures between 1 and 5 degrees Celsius. Do not freeze! Avoid exposing the product to direct light, especially the conjugated antibodies as most conjugates are very sentitive to light.
• Background
  CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.
• Purity
  > 95% (by SDS-PAGE)
• Purification method
  Purified by affinity chromatography
• Datasheet
• References
  *Alpers CE, Hudkins KL, Ferguson M, Johnson RJ, Schatteman GC, Bothwell M: Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys. Lab Invest. 1993 Dec;69(6):703-13., *Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci. 1988 Mar;8(3):860-73., *Schatteman GC, Gibbs L, Lanahan AA, Claude P, Bothwell M: Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci. 1988 Mar;8(3):860-73., *Marano N, Dietzschold B, Earley JJ Jr, Schatteman G, Thompson S, Grob P, Ross AH, Bothwell M, Atkinson BF, Koprowski H: Purification and amino terminal sequencing of human melanoma nerve growth factor receptor. J Neurochem. 1987 Jan;48(1):225-32., *Thompson SJ, Schatteman GC, Gown AM, Bothwell M: A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. Am J Clin Pathol. 1989 Oct;92(4):415-23.
• Properties
  If you buy Antibodies supplied by Exbio they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• About
  Monoclonals of this antigen are available in different clones. Each murine monoclonal anibody has his own affinity specific for the clone. Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes.
• French translation
  anticorps

• Gene target
  CD271   NGFR   monoclonal  
• Gene symbol
  NGFR, NGFR-AS1
• Short name
  Anti-CD271 / NGFR Mab
• Technique
  Antibody, antibodies against human proteins, antibodies for, Monoclonals or monoclonal antibodies
• Host
  Mouse (Mus musculus)
• Isotype
  IgG1
• Alternative name
  Mouse Monoclonal to CD271 / NGFR
• Alternative technique
  antibodies
• Alternative to gene target
  nerve growth factor receptor, CD271 and Gp80-LNGFR and p75(NTR) and p75NTR and TNFRSF16, NGFR and IDBG-57653 and ENSG00000064300 and 4804, nerve growth factor binding, nuclei, Ngfr and IDBG-209608 and ENSMUSG00000000120 and 18053, NGFR and IDBG-638806 and ENSBTAG00000020979 and 353110

Gene info

• Identity
  HGNC:7809
• Gene
  NGFR
• Long gene name
  nerve growth factor receptor
• Synonyms gene name
  • nerve growth factor receptor (TNFR superfamily, member 16)
• Synonyms
  • TNFRSF16
  • CD271
  • p75NTR
• Synonyms name
  • low affinity nerve growth factor receptor
  • TNFR superfamily, member 16
• GenBank acession
  • M14764
• Locus
  17q21.33
• Discovery year
  2001-06-22
• Entrez gene record
  4804
• Pubmed identfication
  • 3022937
  • 3006050
• Classification
  • CD molecules
  • MicroRNA protein coding host genes
  • Tumor necrosis factor receptor superfamily
• VEGA ID
  OTTHUMG00000161495

Gene info

• Identity
  HGNC:55555
• Gene
  NGFR-AS1
• Long gene name
  NGFR antisense RNA 1
• Locus
  17q21.33
• Discovery year
  2021-04-07
• Entrez gene record
  100288866
• RefSeq identity
  • NR_103773
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Similar products