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Jak3 Tyr980 Tyr981 Antibody ALEXA FLUOR

Jak3 Tyr980 Tyr981 Antibody ALEXA FLUOR is available 5 times from Bioss primary conjugated antibodies. alexa fluor labs

bs-3208R-A350 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 350 size: 100ul | 398.16 USD

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bs-3208R-A488 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 488 size: 100ul | 398.16 USD

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bs-3208R-A555 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 555 size: 100ul | 398.16 USD

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bs-3208R-A594 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 594 size: 100ul | 398.16 USD

Long name Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 594 Conjugated
Also known as Anti-Jak3 Tyr980 + Tyr981 PAb ALEXA FLUOR 594
Conjugated with ALEXA FLUOR® 594
Excitation emission 590nm/617nm
Properties For facs or microscopy Alexa 1 conjugate.If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies. ALEXA FLUOR they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
Conjugation Alexa Fluor,ALEXA FLUOR® 594
Conjugated Alexa conjugate 1
French translation anticorps
Label ALEXA FLUOR 594
Alternative name Janus kinase 3 (Tyr980 and Tyr981) (Antibody to), ALEXA FLUOR 594
MeSH Data
Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
Product images
    #bs#.jpgFormalin-fixed and paraffin embedded mouse spleen labeled with Anti-Phospho-Jak3 (Tyr980 + Tyr981)Polyclonal Antibody, Unconjugated (bs-3208R)  at 1:200, followed by conjugation to the secondary antibody and DAB staining#.png
Product files

bs-3208R-A647 | Jak3 (Tyr980 + Tyr981) Antibody, ALEXA FLUOR 647 size: 100ul | 398.16 USD

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Modification Phosphorylation
Clonality Polyclonal
Category Conjugated Primary Antibodies
Host Organism Rabbit (Oryctolagus cuniculus)
Source KLH conjugated synthetic phosphopeptide derived from human Jak3 around the phosphorylation site of Tyr980/981
Swiss Prot P52333
Specificity This is a highly specific antibody against Jak3 Tyr980 + Tyr981.
Immunogen range 971-990/1124
Subcellular location Cytoplasm, Cell membrane
Tested applications IF(IHC-P)
Clone Polyclonal antibody
Modification Site Tyr980 + Tyr981
Synonyms JAKL; LJAK; JAK-3; L-JAK; JAK3_HUMAN; Tyrosine-protein kinase JAK3; Janus kinase 3; Leukocyte janus kinase; JAK3
Purification Purified by Protein A.
Crossreactivity Human, Mouse, Rat
Gene ID Number 3718
Recommended dilutions IF(IHC-P)(1:50-200)
Background of the antigen Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion.
Concentration 1ug per 1ul
Target Antigen Jak3 Tyr980 + Tyr981
Storage conditions Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
Cross-reactive species details Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Gene targetJak3 Tyr980 Tyr981
Short name Jak3 (Tyr980 + Tyr981) Antibody,
Technique Antibody
Alternative technique antibodies
Alternative to gene target Janus kinase 3, JAK-3 and JAK3_HUMAN and JAKL and L-JAK and LJAK, JAK3 and IDBG-37201 and ENSG00000105639 and 3718, transferase activity, Plasma membranes, Jak3 and IDBG-166648 and ENSMUSG00000031805 and 16453, BT.44422 and IDBG-641863 and ENSBTAG00000020904 and 538276
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