flt3-Ligand, human recombinant

  • Catalog number
    4085-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    Fms-related tyrosine kinase 3 ligand
  • Alternative_names
    Fms-related tyrosine kinase 3 ligand, Short name=Flt3 ligand, Short name=Flt3L, SL cytokine
  • Description
    A member of a small family of growth factors that stimulate the proliferation of hematopoietic cells
  • Recombinant
    Yes
  • Source
    E. coli
  • Purity by SDS PAGE
    ≥98%
  • Assay
    SDS-PAGE
  • Purity
    ≥98%
  • Biological activity
    The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human AML5 cells is 1 x 10⁶ units/mg.
  • Molecular Weight
    17.6 kDa
  • Storage Temp
    -20°C
  • Shipping
    Gel pack
  • Shelf Life
    12 months
  • Appearance
    Lyophilized protein
  • Physical form description
    Sterile filtered and lyophilized with no additives. The protein may appear as a haze of film, which is difficult to see at the bottom of the vial.
  • Reconstitution Instructions
    Reconstitute in H₂O to a concentration of 0.1 – 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.
  • Background Information
    Human flt3-Ligand (flk2-ligand) stimulates the proliferation and colony formation of certain bone marrow precursor cells including CD34+ cells. Recombinant human flt3-ligand is a soluble 17.6 kDa polypeptide containing 155 amino acid residues, which comprises the extraCellular domain of the transmembrane flt3-ligand protein.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Additional description
    FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
  • Additional source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
  • Short name
    flt3-Ligand, recombinant
  • Technique
    Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
  • Species
    Human, Humans
  • Alternative name
    fms-related tyrosine kinase 3-Ligand, H. sapiens Rec.
  • Alternative technique
    rec
  • Alternative to gene target
    fms-related tyrosine kinase 3, CD135 and FLK-2 and FLK2 and STK1, FLT3 and IDBG-19891 and ENSG00000122025 and 2322, transferase activity, nuclei, Flt3 and IDBG-209045 and ENSMUSG00000042817 and 14255, BT.28173 and IDBG-630678 and ENSBTAG00000018572 and 512700
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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