Vatalanib, Free Base

• Catalog number
  2026-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  CGP-79787; PTK 787; ZK222584
• Description
  Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter.  At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM).  On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).
• CAS Number
  212141-54-3
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₅ClN₄
• Molecular Weight
  346.81
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (25 mg/ml) or EtOH (~ 6 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A potent inhibitor of the VEGFR tyrosine kinases
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• MDL Number
  MFCD08458963
• PubChem CID
  151194
• PubChem CID Link
• SMILES
  C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4
• InChi
  InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24- 25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)
• InChi Key
  YCOYDOIWSSHVCK-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Vatalanib   Free   Base  
• Short name
  Vatalanib, Free Base
• Alternative name
  Vatalanib, Free Base

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