Doramapimod, p38 MAP kinase inhibitor

• Catalog number
  SIH-442-25MG
• Price
  Please ask
• Size
  25 mg

• Stock availabilitIn Stock
  In Stock
• CAS number
  285983-48-4
• Description
  p38 MAP kinase inhibitor
• Molecular weight
  527,7 g/mol
• Primary research fields
  Cell Signaling, Cancer, Apoptosis, Cancer Growth Inhibitors, Tyrosine Kinase Inhibitors
• Other name
  JNK Inhibitor XVII, BIRB796, 1-[5-tert-butyl-2-(4-methylphenyl)pyrazol-3-yl]-3-[4-(2-morpholin-4-ylethoxy)naphthalen-1-yl]urea
• Product category
  Small Molecules
• Product type
  Inhibitor
• Chemical formula
  C31H37N5O3
• Origin
  Synthetic
• Purity pourcentage
  ≥99% (HPLC)
• Soluble in
  Soluble in DMSO
• Physical appearance
  White solid
• Storage recommendations
  -20ºC
• Shipping recommendations
  Shipped Ambient
• Safety information
  Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
• PubChem number
  156422
• Scientific context
  Doramapimod is a highly potent and selective inhibitor of p38α MAPK. It specifically blocks TNFα release.
• Bibliography
  1. Pargellis C., et al. (2002). Nat Structural Biol. 9(4): 268–272.
• Release date
  1-Oct-2014
• PubMed number
  Refer to PubMed
• Tested applications
  To be tested
• Tested reactivity
  To be tested
• Representative figure link
• Representative figure legend
  Chemical structure of Doramapimod (SIH-442), a p38 MAP kinase inhibitor. CAS #: 285983-48-4. Molecular Formula: C31H37N5O3. Molecular Weight: 527.7 g/mol. Chemical structure of Doramapimod, a p38 MAP kinase inhibitor (SIH-442). CAS # 285983-48-4. Molecular Formula: C31H37N5O3.
• Warning information
  Non-hazardous
• Country of production
  Canada
• Total weight kg
  0.25
• Net weight g
  0.025
• Other related products
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Doramapimod   p38   MAP   kinase   inhibitor  
• Gene symbol
  MOAP1, MAP7, MASP2, MASP1
• Short name
  Doramapimod, p38 MAP kinase inhibitor
• Alternative name
  Doramapimod, p38 mitogen-stimulated protein kinase phosphorylation catalyst suppressor

Gene info

• Identity
  HGNC:16658
• Gene
  MOAP1
• Long gene name
  modulator of apoptosis 1
• Synonyms
  • MAP-1
  • PNMA4
• Synonyms name
  • paraneoplastic Ma antigen family member 4
• GenBank acession
  • BC015044
• Locus
  14q32.12
• Discovery year
  2002-11-13
• Entrez gene record
  64112
• Pubmed identfication
  • 11060313
• Classification
  • Paraneoplastic Ma antigens
• VEGA ID
  OTTHUMG00000169184

Gene info

• Identity
  HGNC:6869
• Gene
  MAP7
• Long gene name
  microtubule associated protein 7
• Synonyms
  • E-MAP-115
• Synonyms name
  • ensconsin
• GenBank acession
  • X73882
• Locus
  6q23.3
• Discovery year
  1999-01-22
• Entrez gene record
  9053
• Pubmed identfication
  • 8408219
• RefSeq identity
  • NM_003980
• VEGA ID
  OTTHUMG00000015646

Gene info

• Identity
  HGNC:6902
• Gene
  MASP2
• Long gene name
  MBL associated serine protease 2
• Synonyms gene
  • MASP1P1
• Synonyms gene name
  • mannan-binding lectin serine protease 2
  • mannan-binding lectin serine peptidase 1 pseudogene 1
  • mannan-binding lectin serine protease 1 pseudogene 1
• Synonyms
  • Map19
  • sMAP
  • MAP-2
• Synonyms name
  • mannose-binding lectin-associated serine protease 2
  • mannose-binding lectin associated protein 19
• GenBank acession
  • X98400
• Locus
  1p36.22
• Discovery year
  1998-12-17
• Entrez gene record
  10747
• Pubmed identfication
  • 9087411
  • 9777418
• RefSeq identity
  • NM_006610
• Classification
  • Sushi domain containing
  • Complement system activation components
• VEGA ID
  OTTHUMG00000002121
• Locus Specific Databases
  • MASP2base: Mutation registry for MASP-2 deficiency
  • LRG_82

Gene info

• Identity
  HGNC:6901
• Gene
  MASP1
• Long gene name
  MBL associated serine protease 1
• Synonyms gene
  • CRARF
  • PRSS5
• Synonyms gene name
  • mannan-binding lectin serine protease 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
  • mannan binding lectin serine peptidase 1
• Synonyms
  • MASP
  • Map44
  • MASP-3
  • MAP-1
• Synonyms name
  • C4/C2 activating component of Ra-reactive factor
  • mannose-binding lectin-associated serine protease 1
• GenBank acession
  • D28593
• Locus
  3q27.3
• Discovery year
  1995-07-06
• Entrez gene record
  5648
• Pubmed identfication
  • 8018603
  • 8240317
• RefSeq identity
  • NM_001879
• Classification
  • Serine proteases
  • Complement system activation components
  • Sushi domain containing
• VEGA ID
  OTTHUMG00000156461
• Locus Specific Databases
  • LRG_349

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