Recombinant Human ICOS Ligand / B7-H2 / ICOSLG Protein (Fc tag) 200µg
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Catalog numberPKSH031086-200µg
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PricePlease ask
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Size200µg
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SynonymB7-h2;B7H2;B7RP-1;B7RP1;CD275;GL50;ICOS ligand;ICOS-L;ICOSL;ICOSLG;LICOS
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ActivityNA
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SequenceMet1-Ser258
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Fusion tagC-Fc
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AccessionO75144-1
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Expressed HostHEK293 Cells
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ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity(96.1+2.0) % as determined by SDS-PAGE
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Endotoxin<1.0 EU per µg as determined by the LAL method
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Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass53.7 kDa
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AP Mol Mass66-76 and 33 kDa
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FormulationLyophilized from sterile PBS, pH 7.4
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ReconstitutionPlease refer to it for detailed information.
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BackgroundInducible co-stimulator ligand (ICOSL), also known as B7-H2, is a member of the B7 family of co-stimulatory molecules related to B7-1 and B7-2. It is a transmembrane glycoprotein with extracellular IgV and IgC domains, and binds to ICOS on activated T cells, thus delivers a positive costimulatory signal for optimal T cell function. The structural features of ICOSL are crucial for its costimulatory function. Present study shows that ICOSL displays a marked oligomerization potential, resembling more like B7-1 than B7-2. B7-H2-dependent signaling may play an active role in a proliferative response rather than in cytokine and chemokine production. The CD28/B7 and ICOS/B7-H2 pathways are both critical for costimulating T cell immune responses. Deficiency in either pathway results in defective T cell activation, cytokine production and germinal center formation.Immune CheckpointImmune Checkpoint Detection: Antibodies Immune Checkpoint Detection: ELISA Antibodies Immune Checkpoint Detection: FCM Antibodies Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Targets Co-stimulatory Immune Checkpoint Targets Immunotherapy Cancer Immunotherapy Targeted Therapy
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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DescriptionFAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. Receptor agonists are often tested for drug development.
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SourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolICOSLG, NCAPH2, TUBA3D, HHLA2, ICOS, RNY4P2, LRRC23, NME2, PCDHGB7, CFB
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Short nameRecombinant ICOS Ligand / B7-H2 / ICOSLG Protein (Fc tag) 200µg
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TechniqueRecombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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LabelFc Tag
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SpeciesHuman, Humans
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Alternative nameRec. H. sapiens inducible T-cell co-stimulator Ligand / B7-H2 / inducible T-cellular co-stimulator ligand Protein (fragment c detection labelled) 200µg
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Alternative techniquerec
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Alternative to gene targetinducible T-cell co-stimulator ligand, ICOSLG and IDBG-5107 and ENSG00000160223 and 102723996,23308, protein binding, Plasma membranes, Icosl and IDBG-168471 and ENSMUSG00000000732 and 50723, ICOSLG and IDBG-639662 and ENSBTAG00000014880 and 507857
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Gene info
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Identity
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Gene
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Long gene nameinducible T cell costimulator ligand
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Synonyms gene
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Synonyms gene name
- inducible T-cell costimulator ligand
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2003-12-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- B7 family
- CD molecules
- Receptor ligands
- C2-set domain containing
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenon-SMC condensin II complex subunit H2
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Synonyms gene name
- non-SMC condensin II complex, subunit H2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2006-09-04
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Condensin II subunits
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nametubulin alpha 3d
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2007-02-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tubulins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameHERV-H LTR-associating 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-09-07
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- V-set domain containing
- B7 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinducible T cell costimulator
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Synonyms gene name
- inducible T-cell costimulator
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-02-29
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameRNY4 pseudogene 2
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Synonyms gene name
- RNA, Y4 small cytoplasmic (associated with Ro protein) pseudogene 2
- RNA, Ro-associated Y4 pseudogene 2
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-08-25
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Entrez gene record
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RefSeq identity
Gene info
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Identity
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Gene
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Long gene nameleucine rich repeat containing 23
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Synonyms
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GenBank acession
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Locus
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Discovery year2006-01-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameNME/NM23 nucleoside diphosphate kinase 2
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Synonyms gene name
- non-metastatic cells 2, protein (NM23B) expressed in
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-07-26
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- NME/NM23 family
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameprotocadherin gamma subfamily B, 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-06-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Clustered protocadherins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namecomplement factor B
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Synonyms gene
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Synonyms gene name
- B-factor, properdin
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Synonyms
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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RefSeq identity
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Classification
- Complement system activation components
- Sushi domain containing
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data