Human CellExp™ IL-17A, Human Recombinant
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Catalog number6468-10
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PricePlease ask
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Size10 µg
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SynonymsHuman Cellexp Human Recombinant IL-17A
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Alternative_namesCTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8.
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DescriptionA proinflammatory cytokine produced by activated T cells
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RecombinantYes
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SourceHuman 293 cell expressed
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Purity by SDS PAGE> 95%
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AssaySDS-PAGE
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Endotoxin Level< 1.0 EU per 1 ug of protein
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Biological activityED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts.
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Results5 to 25 ng/ml
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Molecular Weight30 to 35 kDa, homodimer, glycosylated
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Storage Temp-20°C
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Shippinggel pack
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Shelf Life12 months
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AppearanceLyophilized
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Physical form descriptionLyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl.
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Reconstitution InstructionsReconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
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Background InformationInterleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolIL17A, IL36G, IL25, IL22, IL18, IL37, IL6R, IL17C, IL17D, IL31
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Short nameCellExp™ IL-17A, Recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHumans
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Alternative nameH. sapiens CellExp™ Interleukin-17A, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene nameinterleukin 17A
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Synonyms gene
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Synonyms gene name
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-10-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameinterleukin 36 gamma
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 9
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 25
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Synonyms gene
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Synonyms gene name
- interleukin 17E
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-01-26
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Pubmed identfication
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 22
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-03-12
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameinterleukin 18
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Synonyms gene name
- interleukin 18 (interferon-gamma-inducing factor)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-07-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 37
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Synonyms gene
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Synonyms gene name
- interleukin 1 family, member 7 (zeta)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-08-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 6 receptor
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 17C
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Synonyms
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GenBank acession
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Locus
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Discovery year2000-01-20
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 17D
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2000-05-02
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameinterleukin 31
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-11-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Interleukins
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
