Keratin-8, human recombinant
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Catalog number4817-5
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PricePlease ask
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Size5 ug
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SynonymsKeratin type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, KRT8, CYK8, KO, CK8, K2C8, CARD2,
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Alternative_namesKeratin type II cytoskeletal 8, Cytokeratin-8, CK-8, Keratin-8, K8, KRT8, CYK8, KO, CK8, K2C8, CARD2,
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DescriptionKey structural material in skin, hair and nails
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RecombinantYes
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SourceE. coli
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Purity by SDS PAGE≥90%
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AssaySDS-PAGE
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Purity≥90%
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Molecular Weight78.0 kDa
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Storage Temp-20°C
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ShippingBlue ice
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Shelf Life12 months
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Concentration0.1 ug/ul
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AppearanceLiquid
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Physical form descriptionSterile filtered (5 ug/50 ul) in Tris-Acetate (pH 7.5), 1 mM EDTA, 20% glycerol.
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Background InformationKeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Keratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. HepatoCellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18. The recombinant human keratin-8 is expressed in E. coli and purified by proprietary chromatographic techniques.
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HandlingCentrifuge the vial prior to opening.
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UsageFor Research Use Only! Not to be used in humans
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional sourceRecombinants or rec. proteins
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Grouprecombinants
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Gene target
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Gene symbolKRT8P11, KRTAP10-8, KRT8P12
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Short nameKeratin-8, recombinant
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TechniqueRecombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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SpeciesHuman, Humans
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Alternative nameKeratin-8, H. sapiens Rec.
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Alternative techniquerec
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Gene info
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Identity
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Gene
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Long gene namekeratin 8 pseudogene 11
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Synonyms gene
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Synonyms gene name
- keratin 8-like 1
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Synonyms
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Locus
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Discovery year2004-05-27
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Entrez gene record
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RefSeq identity
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekeratin associated protein 10-8
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Synonyms gene
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Synonyms gene name
- keratin associated protein 18-8
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Synonyms
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GenBank acession
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Locus
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Discovery year2003-11-21
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Entrez gene record
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RefSeq identity
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Classification
- Keratin associated proteins
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namekeratin 8 pseudogene 12
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Synonyms gene
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Synonyms gene name
- keratin 8-like 2
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Locus
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Discovery year2005-04-22
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Entrez gene record
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RefSeq identity
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VEGA ID
MeSH Data
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Name
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ConceptScope note: The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data