Leptomycin B, Nuclear export inhibitor

  • Catalog number
    SIH-534-200UG
  • Price
    Please ask
  • Size
    200 µg
  • Stock availabilitIn Stock
    In Stock
  • CAS number
    87081-35-4
  • Description
    Nuclear export inhibitor
  • Molecular weight
    540,7 g/mol
  • Primary research fields
    Cancer, Cancer Growth Inhibitors
  • Other name
    Elactocin, LMB, Mantuamycin, NSC 364372
  • Product category
    Small Molecules
  • Product type
    Inhibitor
  • Chemical formula
    C33H48O6
  • Origin
    Synthetic
  • Purity pourcentage
    >99% (HPLC); NMR (Conforms)
  • Soluble in
    May be dissolved into DMSO or ethanol. Use solutions made with DMSO within 24 hours.
  • Physical appearance
    Solution in ethanol (0.2 mg/ml)
  • Storage recommendations
    -20ºC
  • Shipping recommendations
    Shipped Ambient
  • Safety information
    Classification: B2 Flammable liquid - Flammable liquid D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion, Toxic by skin absorption Hazard statement(s): H225 Highly flammable liquid and vapour. H301 + H311 Toxic if swallowed or in contact with skin H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H370 Causes damage to organs. Precautionary statement(s): P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.
  • PubChem number
    6917907
  • Scientific context
    Leptomycin B is an inhibitor of nuclear export proteins. It is an anti-fungal, and anti-tumor cytotoxin.
  • Release date
    30/Aug/2016
  • PubMed number
    Refer to PubMed
  • Tested applications
    To be tested
  • Tested reactivity
    To be tested
  • Representative figure legend
    Chemical structure of Leptomycin B (SIH-534), a Nuclear export inhibitor. CAS #: 87081-35-4. Molecular Formula: C33H48O6. Molecular Weight: 540.7 g/mol. Chemical structure of Leptomycin B, a Nuclear export inhibitor (SIH-534). CAS # 87081-35-4. Molecular Formula: C33H48O6.
  • Warning information
    Non-hazardous
  • Country of production
    Canada
  • Total weight kg
    0.25
  • Net weight g
    0.0002
  • Additional description
    Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
  • Gene target
  • Short name
    Leptomycin B, export inhibitor
  • Alternative name
    Leptomycin B, Nuclear export suppressor
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