Leptomycin B, Nuclear export inhibitor
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Catalog number
SIH-534-1MG
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Price
Please ask
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Size
1 mg
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Stock availabilitIn Stock
In Stock
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CAS number
87081-35-4
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Description
Nuclear export inhibitor
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Molecular weight
540,7 g/mol
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Primary research fields
Cancer, Cancer Growth Inhibitors
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Other name
Elactocin, LMB, Mantuamycin, NSC 364372
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Product category
Small Molecules
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Product type
Inhibitor
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Chemical formula
C33H48O6
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Origin
Synthetic
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Purity pourcentage
>99% (HPLC); NMR (Conforms)
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Soluble in
May be dissolved into DMSO or ethanol. Use solutions made with DMSO within 24 hours.
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Physical appearance
Solution in ethanol (0.2 mg/ml)
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Storage recommendations
-20ºC
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Shipping recommendations
Shipped Ambient
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Safety information
Classification: B2 Flammable liquid - Flammable liquid D1B Toxic Material Causing Immediate and Serious Toxic Effects - Toxic by ingestion, Toxic by skin absorption Hazard statement(s): H225 Highly flammable liquid and vapour. H301 + H311 Toxic if swallowed or in contact with skin H315 Causes skin irritation. H319 Causes serious eye irritation. H331 Toxic if inhaled. H370 Causes damage to organs. Precautionary statement(s): P210 Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray. P280 Wear protective gloves/ protective clothing. P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P307 + P311 IF exposed: Call a POISON CENTER or doctor/ physician.
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PubChem number
6917907
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Scientific context
Leptomycin B is an inhibitor of nuclear export proteins. It is an anti-fungal, and anti-tumor cytotoxin.
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Release date
30/Aug/2016
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PubMed number
Refer to PubMed
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Tested applications
To be tested
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Tested reactivity
To be tested
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Representative figure legend
Chemical structure of Leptomycin B (SIH-534), a Nuclear export inhibitor. CAS #: 87081-35-4. Molecular Formula: C33H48O6. Molecular Weight: 540.7 g/mol. Chemical structure of Leptomycin B, a Nuclear export inhibitor (SIH-534). CAS # 87081-35-4. Molecular Formula: C33H48O6.
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Warning information
Non-hazardous
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Country of production
Canada
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Total weight kg
0.25
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Net weight g
0.001
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Leptomycin B, export inhibitor
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Alternative name
Leptomycin B, Nuclear export suppressor
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