Ro 48-8071 fumarate

• Catalog number
  B1042-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  (4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone fumarate
• Description
  Ro 48-8071 is a selective 2,3-Oxidosqualene:lanosterol cyclase (OSC) inhibitor (IC₅₀ = 6.5 nM); blocks cholesterol synthesis in HepG2 cells.  Ro 48-8071 exerts strong anti-angiogenic activity by impairing endothelial cell adhesion and migration, and by blocking vessel formation in angiogenesis assays.
• CAS Number
  189197-69-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₂₇BrFNO₂.C₄H₄O₄
• Molecular Weight
  564.44
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>50 mg/ml) or H₂O (>5 mg/ml)
• Handling
  Protect from air and moisture
• Tag Line
  A selective 2,3-Oxidosqualene:lanosterol cyclase (OSC) inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• PubChem CID
  9959583
• PubChem CID Link
• SMILES
  CN(CCCCCCOC1=CC(=C(C=C1)C(=O)C2=CC=C(C=C2)Br)F)CC=C.C(=CC(=O)O)C(=O)O
• InChi
  InChI=1S/C23H27BrFNO2.C4H4O4/c1-3-14-26(2)15-6-4-5-7-16-28-20-12-13-21(22(25)17-20)23(27)18-8-10-19(24)11-9-18;5-3(6)1-2-4(7)8/h3,8-13,17H,1,4-7,14-16H2,2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChi Key
  XCYAYLWZCRGKDS-WLHGVMLRSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  48-8071   fumarate  
• Gene symbol
  SNORD115-48, IGLV5-48, IGHV3-48, RNU6-48P, UTP18, MIR8071-2, MIR8071-1, HAUS8, SNORD115-45
• Short name
  Ro 48-8071 fumarate
• Alternative name
  Ro 48-8071 fumarate

Gene info

• Identity
  HGNC:33343
• Gene
  SNORD115-48
• Long gene name
  small nucleolar RNA, C/D box 115-48
• Synonyms
  • HBII-52-48
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-16
• Entrez gene record
  100033822
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003362.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:5925
• Gene
  IGLV5-48
• Long gene name
  immunoglobulin lambda variable 5-48 (non-functional)
• Synonyms gene name
  • immunoglobulin lambda variable 5-48
• GenBank acession
  • Z73649
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28780
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000151041

Gene info

• Identity
  HGNC:5606
• Gene
  IGHV3-48
• Long gene name
  immunoglobulin heavy variable 3-48
• GenBank acession
  • M99675
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28424
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151959

Gene info

• Identity
  HGNC:34292
• Gene
  RNU6-48P
• Long gene name
  RNA, U6 small nuclear 48, pseudogene
• Synonyms gene
  • RNU6-48
• Synonyms gene name
  • RNA, U6 small nuclear 48
• Locus
  1p36.11
• Discovery year
  2008-06-10
• Entrez gene record
  100887744
• RefSeq identity
  • NR_049779

Gene info

• Identity
  HGNC:24274
• Gene
  UTP18
• Long gene name
  UTP18 small subunit processome component
• Synonyms gene
  • WDR50
• Synonyms gene name
  • WD repeat domain 50
  • UTP18 small subunit (SSU) processome component homolog (yeast)
• Synonyms
  • CGI-48
• GenBank acession
  • AF151806
• Locus
  17q21.33
• Discovery year
  2005-02-01
• Entrez gene record
  51096
• Pubmed identfication
  • 10810093
  • 8619474
  • 15590835
• RefSeq identity
  • NM_016001
• Classification
  • UTPb subcomplex
  • WD repeat domain containing
• VEGA ID
  OTTHUMG00000162370

Gene info

• Identity
  HGNC:49958
• Gene
  MIR8071-2
• Long gene name
  microRNA 8071-2
• Synonyms
  • hsa-mir-8071-2
• Locus
  14q32.33
• Discovery year
  2014-03-24
• Entrez gene record
  102466889
• RefSeq identity
  • NR_107059
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:50041
• Gene
  MIR8071-1
• Long gene name
  microRNA 8071-1
• Synonyms
  • hsa-mir-8071-1
• Locus
  14q32.33
• Discovery year
  2014-03-24
• Entrez gene record
  102465871
• RefSeq identity
  • NR_107038
• Classification
  • MicroRNAs

Gene info

• Identity
  HGNC:30532
• Gene
  HAUS8
• Long gene name
  HAUS augmin like complex subunit 8
• Synonyms gene
  • HICE1
• Synonyms gene name
  • HEC1/NDC80 interacting, centrosome associated 1
• Synonyms
  • MGC20533
  • NY-SAR-48
• GenBank acession
  • BC004398
• Locus
  19p13.11
• Discovery year
  2008-12-16
• Entrez gene record
  93323
• Pubmed identfication
  • 19427217
• RefSeq identity
  • NM_001011699
• Classification
  • HAUS augmin like complex
• VEGA ID
  OTTHUMG00000182672

Gene info

• Identity
  HGNC:33064
• Gene
  SNORD115-45
• Long gene name
  small nucleolar RNA, C/D box 115-45
• Synonyms
  • HBII-52-45
  • SNORD115-48
• Locus
  15q11.2
• Discovery year
  2011-08-22
• Entrez gene record
  100036566
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003498
• Classification
  • Small nucleolar RNAs, C/D box

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