anti- CHMP4B antibody

• Catalog number
  FNab01660
• Price
  Please ask
• Size
  2X100μg

• Form
  liquid
• Purification
  Immunogen affinity purified
• Purity
  ≥95% as determined by SDS-PAGE
• Storage
  PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
• Background
  This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.
• Immunogen
  chromatin modifying protein 4B
• Synonyms
  C20orf178, SHAX1
• Calculated MW
  35 kDa
• Uniprot ID
  Q9H444
• Specificity
  Human, Mouse, Rat
• Tested Application
  ELISA, WB, IHC
• Recommended dilution
  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
• Image1
  Immunohistochemistry of paraffin-embedded human oesophagus cancer using FNab01660(CHMP4B antibody) at dilution of 1:50
• Image4
  mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab01660(CHMP4B antibody) at dilution of 1:1000
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• Properties
  If you buy Antibodies supplied by FineTest they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  CHMP4B  
• Gene symbol
  CHMP4B
• Short name
  anti- CHMP4B antibody
• Technique
  Antibody, anti, antibody to, antibodies against human proteins, antibodies for
• Host
  Rabbit
• Isotype
  IgG
• Alternative name
  antibody to- CHMP4B (antibody to-)
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:16171
• Gene
  CHMP4B
• Long gene name
  charged multivesicular body protein 4B
• Synonyms gene
  • C20orf178
• Synonyms gene name
  • chromosome 20 open reading frame 178
  • chromatin modifying protein 4B
• Synonyms
  • dJ553F4.4
  • Shax1
  • SNF7-2
  • VPS32B
• GenBank acession
  • AL050349
• Locus
  20q11.22
• Discovery year
  2001-07-17
• Entrez gene record
  128866
• Pubmed identfication
  • 14678797
• Classification
  • ESCRT-III
  • Charged multivesicular body proteins
• VEGA ID
  OTTHUMG00000032272

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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