A specific, ATP-competitive, small-molecule inhibitor of the receptor tyrosine kinases (RTKs) c-Met and anaplastic lymphoma kinase (ALK). Iinhibits tyrosine phosphorylation of activated ALK at nanomolar concentrations. Inhibits the growth and survival of cell lines dependent upon c-Met or ALK enzymatic activity.
Is this a salt?
Is it cell-permeable?
≥98% by HPLC
Maximum time for storage
Protect from air and light
For cells, cell lines and tissues in culture till half confluency.
Crizotinib for activation
Crizotinib to measure cellular activation