Recombinant Mouse Tissue Inhibitor of Metalloproteinases 2/TIMP-2 Protein(C-6His) 50µg
-
Catalog numberPKSM041160-50µg
-
PricePlease ask
-
Size50µg
-
-
ActivityNA
-
SynonymTIMP-2; CSC-21Ktissue inhibitor of metalloproteinase 2; metalloproteinase inhibitor 2; TIMP metalloproteinase inhibitor 2; Tissue inhibitor of metalloproteinase 2.
-
SequenceCys27-Pro220
-
Fusion tagC-6His
-
AccessionP25785
-
Expressed HostHuman Cells
-
ShippingThe product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
-
Purity>95% as determined by reducing SDS-PAGE.
-
Stability and StorageStore at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles
-
Mol Mass22.5 kDa
-
AP Mol Mass21kDa
-
FormulationSupplied as a 0.2 μm filtered solution of 20mM TrisHCl,150mM NaCl,pH7.5.
-
BackgroundMouse Metalloproteinase inhibitor 2(TIMP-2), belongs to a family of proteins that regulate the activation and proteolytic activity of matrix metalloproteinases (MMPs). There are four mammalian members of the family; TIMP-1, TIMP-2, TIMP-3, and TIMP-4. The TIMP-2 is detected in testis, retina, hippocampus and cerebral cortex. The function of TIMP 2 protein is to inhibit MMPs non covalently by the formation of binary complexes. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.And the interaction with MMP-14 facilitates the activation of pro-MMP-2.It has been shown that the binding of TIMP 2 to a3b1 integrin results in the inhibition of endothelial cell proliferation and angiogenesis.
-
DescriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme. 6
-
TestMouse or mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab. Mouse are mature after 40 days for females and 55 days for males. The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year. Transgenic, knock-out, congenic and inbread strains are known for C57BL/6, A/J, BALB/c, SCID while the CD-1 is outbred as strain.
-
Latin nameMus musculus
-
SourceRecombinants or rec. proteins
-
Grouprecombinants
-
Gene target
-
Gene symbolTIMP2, TIMP1, MIR1289-2, MIR521-2, MIR509-2, MIR512-2, MIR7-2, MIR329-2, RNU6-2, KRTAP13-2
-
Short nameRecombinant Mouse Tissue Inhibitor of Metalloproteinases 2/TIMP-2 Protein(C-6His) 50µg
-
TechniqueRecombinant, tissue, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. tissues
-
Hostmouse
-
SpeciesMouse, Mouses
-
Alternative nameRec. Mouse Tissue suppressor on Metalloproteinases 2/TIMP-2 Protein(C-6His) 50µg
-
Alternative techniquerec, tissues, murine
-
Tissuetissue
-
Gene info
-
Identity
-
Gene
-
Long gene nameTIMP metallopeptidase inhibitor 2
-
Synonyms gene name
- tissue inhibitor of metalloproteinase 2
-
Synonyms
-
Locus
-
Discovery year1992-06-18
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Tissue inhibitor of metallopeptidases
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameTIMP metallopeptidase inhibitor 1
-
Synonyms gene
-
Synonyms gene name
- tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
-
Synonyms
-
Locus
-
Discovery year1986-01-01
-
Entrez gene record
-
RefSeq identity
-
Classification
- Tissue inhibitor of metallopeptidases
-
VEGA ID
-
Locus Specific Databases
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1289-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1289 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 521-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2005-07-15
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR515 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 509-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR506 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 512-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2005-07-15
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR506 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 7-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2004-04-23
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR7 family
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 329-2
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2005-07-11
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR329 family
Gene info
-
Identity
-
Gene
-
Long gene nameRNA, U6 small nuclear 2
-
Synonyms
-
Locus
-
Discovery year2008-06-10
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nuclear RNAs
Gene info
-
Identity
-
Gene
-
Long gene namekeratin associated protein 13-2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-02-21
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Keratin associated proteins
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.
-
Tree numbers
- E01.370.225.500.620.720
- E01.370.225.750.600.720
- E05.200.500.620.720
- E05.200.750.600.720
-
Qualifiersclassification, economics, history, instrumentation, methods, standards, trends, utilization, veterinary, statistics & numerical data, ethics