a1-Antitrypsin (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI)

• Catalog number
  MBS603088
• Price
  Please ask
• Size
  0.5 mg

• Products_type
  Antibody
• Products_short_name
  [a1-Antitrypsin]
• Products_name_syn
  [Anti -a1-Antitrypsin (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI)]
• Other_names
  [alpha-1-antitrypsin; Alpha-1-antitrypsin; alpha-1-antitrypsin; serpin A1; alpha-1-antiproteinase; alpha-1-antitrypsin null; alpha-1 protease inhibitor; protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin; serine (or cysteine) proteinase inhibitor, clade A, member 1; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1]
• Other_gene_names
  [SERPINA1; SERPINA1; PI; A1A; AAT; PI1; A1AT; PRO2275; alpha1AT; AAT; PI; SPAAT]
• Clonality
  Monoclonal
• Clone
  [8.F.14]
• Reactivity
  Human
• Specificity
  Recognizes human alpha-1-Antitrypsin. No crossreactivity with alpha-1-antichymotrypsin.
• Purity
  Purified Chromatographically purified
• Form
  Supplied as a liquid in PBS, pH 7.5. No preservative added.
• Storage_stability
  May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
• Tested_application
  ELISA (EL/EIA)
• Description
  The a1-Antitrypsin (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI) is a α- or alpha protein sometimes glycoprotein present in blood. Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  a1-Antitrypsin   AAT   alpha-1-AT   alpha1   Proteinase   Inhibitor   alpha1  
• Gene symbol
  TRI-AAT1-1, SLC33A1, NBN, TRI-AAT4-1, TRI-AAT7-1, TRI-AAT12-1, TRI-AAT3-1, TRI-AAT11-1, TRI-AAT2-1, TRI-AAT6-1
• Short name
  a1-Antitrypsin (AAT, alpha-1-AT, alpha1 Proteinase Inhibitor, alpha1 PI)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  a1-Antitrypsin (AAT, a-1-AT, alpha1 Proteinase suppressor, alpha1 PI)

Gene info

• Identity
  HGNC:34812
• Gene
  TRI-AAT1-1
• Long gene name
  tRNA-Ile (anticodon AAT) 1-1
• Synonyms gene
  • TRNAI12
• Synonyms gene name
  • transfer RNA isoleucine 12 (anticodon AAU)
  • transfer RNA-Ile (AAT) 1-1
• Synonyms
  • tRNA-Ile-AAT-1-1
• GenBank acession
  • HG983843
• Locus
  6p11.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189249
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:95
• Gene
  SLC33A1
• Long gene name
  solute carrier family 33 member 1
• Synonyms gene
  • ACATN
  • SPG42
• Synonyms gene name
  • acetyl-Coenzyme A transporter
  • spastic paraplegia 42 (autosomal dominant)
  • solute carrier family 33 (acetyl-CoA transporter), member 1
• Synonyms
  • AT-1
  • AT1
• GenBank acession
  • D88152
• Locus
  3q25.31
• Discovery year
  1999-02-12
• Entrez gene record
  9197
• Pubmed identfication
  • 9096318
  • 19061983
• RefSeq identity
  • NM_004733
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000158481

Gene info

• Identity
  HGNC:7652
• Gene
  NBN
• Long gene name
  nibrin
• Synonyms gene
  • NBS
  • NBS1
• Synonyms gene name
  • Nijmegen breakage syndrome 1 (nibrin)
• Synonyms
  • ATV
  • AT-V2
  • AT-V1
• GenBank acession
  • AF058696
• Locus
  8q21.3
• Discovery year
  1997-11-28
• Entrez gene record
  4683
• Pubmed identfication
  • 9590181
  • 9590180
• RefSeq identity
  • NM_001024688
• Classification
  • MRN complex
  • BRCA1 C complex
• VEGA ID
  OTTHUMG00000153546
• Locus Specific Databases
  • Global Variome shared LOVD
  • LRG_158

Gene info

• Identity
  HGNC:34961
• Gene
  TRI-AAT4-1
• Long gene name
  tRNA-Ile (anticodon AAT) 4-1
• Synonyms gene
  • TRNAI24
• Synonyms gene name
  • transfer RNA isoleucine 24 (anticodon AAU)
  • transfer RNA-Ile (AAT) 4-1
• Synonyms
  • tRNA-Ile-AAT-4-1
• GenBank acession
  • HG983846
• Locus
  17p13.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189393
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34710
• Gene
  TRI-AAT7-1
• Long gene name
  tRNA-Ile (anticodon AAT) 7-1
• Synonyms gene
  • TRNAI8
• Synonyms gene name
  • transfer RNA isoleucine 8 (anticodon AAU)
  • transfer RNA-Ile (AAT) 7-1
• Synonyms
  • tRNA-Ile-AAT-7-1
• GenBank acession
  • HG983853
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189401
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35054
• Gene
  TRI-AAT12-1
• Long gene name
  tRNA-Ile (anticodon AAT) 12-1
• Synonyms gene
  • TRNAI30P
• Synonyms gene name
  • transfer RNA isoleucine 30 (anticodon AAU) pseudogene
  • transfer RNA-Ile (AAT) 12-1
• Synonyms
  • tRNA-Ile-AAT-12-1
• GenBank acession
  • HG983859
• Locus
  20q13.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189481
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34776
• Gene
  TRI-AAT3-1
• Long gene name
  tRNA-Ile (anticodon AAT) 3-1
• Synonyms gene
  • TRNAI11
• Synonyms gene name
  • transfer RNA isoleucine 11 (anticodon AAU)
  • transfer RNA-Ile (AAT) 3-1
• Synonyms
  • tRNA-Ile-AAT-3-1
• GenBank acession
  • HG983845
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189213
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:35047
• Gene
  TRI-AAT11-1
• Long gene name
  tRNA-Ile (anticodon AAT) 11-1
• Synonyms gene
  • TRNAI29P
• Synonyms gene name
  • transfer RNA isoleucine 29 (anticodon AAU) pseudogene
  • transfer RNA-Ile (AAT) 11-1
• Synonyms
  • tRNA-Ile-AAT-11-1
• GenBank acession
  • HG983858
• Locus
  12q24.33
• Discovery year
  2008-08-29
• Entrez gene record
  100189474
• RefSeq identity
  • NG_008532
• Classification
  • Cytoplasmic transfer RNA pseudogenes

Gene info

• Identity
  HGNC:34630
• Gene
  TRI-AAT2-1
• Long gene name
  tRNA-Ile (anticodon AAT) 2-1
• Synonyms gene
  • TRNAI4
• Synonyms gene name
  • transfer RNA isoleucine 4 (anticodon AAU)
  • transfer RNA-Ile (AAT) 2-1
• Synonyms
  • tRNA-Ile-AAT-2-1
• GenBank acession
  • HG983844
• Locus
  6p22.1
• Discovery year
  2008-08-29
• Entrez gene record
  100189071
• Classification
  • Cytoplasmic transfer RNAs

Gene info

• Identity
  HGNC:34940
• Gene
  TRI-AAT6-1
• Long gene name
  tRNA-Ile (anticodon AAT) 6-1
• Synonyms gene
  • TRNAI22
• Synonyms gene name
  • transfer RNA isoleucine 22 (anticodon AAU)
  • transfer RNA-Ile (AAT) 6-1
• Synonyms
  • tRNA-Ile-AAT-6-1
• GenBank acession
  • HG983852
• Locus
  6p22.2
• Discovery year
  2008-08-29
• Entrez gene record
  100189372
• Classification
  • Cytoplasmic transfer RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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