Caspase-3 Antibody (phospho-S12)

  • Catalog number
    F48684-0.08ML
  • Price
    Please ask
  • Size
    0.08 ml
  • Category
    Antibody
  • Concentration
    In 1X PBS pH 7.4 with 0.09% sodium azide
  • Form
    Antigen affinity purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    Caspase-3 (phospho-S12)
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Mouse (Mus musculus) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    DB, ELISA
  • Recommended dilutions
    Dot blot: 1:500
  • Notes
    Titration of the phospho-Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This phospho-Caspase-3 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    P70677
  • Purity
    Antigen affinity
  • Description
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
  • Immunogen
    This phospho-Caspase-3 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS12 of mouse CASP3.
  • Storage
    Aliquot the phospho-Caspase-3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    RPS12, MRPS34, PSMD7, HTR1B
  • Short name
    Anti-Caspase-3 (phospho-S12)
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit Ig
  • Alternative name
    Antibodies to Caspase-3 (phospho-S12)
  • Alternative technique
    antibodies
Gene info
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    proteasome 26S subunit, non-ATPase 7
  • Synonyms gene name
    • proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)
    • proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
  • Synonyms
  • Synonyms name
  • GenBank acession
  • Locus
  • Discovery year
    1991-06-05
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Proteasome
    • JAMM/MPN+ metallopeptidase family
  • VEGA ID
Gene info
  • Identity
  • Gene
  • Long gene name
    5-hydroxytryptamine receptor 1B
  • Synonyms gene name
    • 5-hydroxytryptamine (serotonin) receptor 1B
    • 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1992-06-12
  • Entrez gene record
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • 5-hydroxytryptamine receptors, G protein-coupled
  • VEGA ID
MeSH Data
  • Name
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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