Caspase-3 Antibody

  • Catalog number
    F41376-0.08ML
  • Price
    Please ask
  • Size
    0.08 ml
  • Category
    Antibody
  • Concentration
    In 1X PBS pH 7.4 with 0.09% sodium azide
  • Form
    Purified
  • Conjugation
    Unconjugated
  • Clone
    Polyclonal antibody
  • Recognised antigen
    Caspase-3
  • Host animal
    Rabbit (Oryctolagus cuniculus)
  • Clonality
    Polyclonal (rabbit origin)
  • Species reactivity
    Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
  • Tested applications
    WB, IHC, FACS, ELISA
  • Recommended dilutions
    Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
  • Notes
    Titration of the Caspase-3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
  • Intented use
    This Caspase-3 antibodyis to be used only for research purposes and not for diagnostics..
  • Uniprot
    P42574
  • Purity
    Purified
  • Description
    This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq].
  • Immunogen
    A portion of amino acids 219-248 from the human protein was used as the immunogen for this Caspase-3 antibody.
  • Storage
    Aliquot the Caspase-3 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
  • Properties
    If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
  • Additional description
    Human and some mouse caspases are active in apoptosis and cell death and even in necrosis and inflammation. CASP Gene and orthologous enzymes have been identifies successfully in the signal transduction cascade and pathways.
  • French translation
    anticorps
  • Gene target
  • Gene symbol
    CASP1P3, CASP3, CASP3P1
  • Short name
    Anti-Caspase-3
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Isotype
    Rabbit Ig
  • Alternative name
    Antibodies to Caspase-3
  • Alternative technique
    antibodies
Gene info
  • Identity
  • Gene
  • Long gene name
    caspase 1 pseudogene 3
  • Synonyms gene name
    • caspase 1, apoptosis-related cysteine peptidase pseudogene 3
  • Locus
  • Discovery year
    2012-02-24
  • Entrez gene record
  • RefSeq identity
Gene info
  • Identity
  • Gene
  • Long gene name
    caspase 3
  • Synonyms gene name
    • caspase 3, apoptosis-related cysteine protease
    • caspase 3, apoptosis-related cysteine peptidase
  • Synonyms
  • GenBank acession
  • Locus
  • Discovery year
    1996-07-22
  • Entrez gene record
    836
  • Pubmed identfication
  • RefSeq identity
  • Classification
    • Caspases
    • Small nucleolar RNA protein coding host genes
  • VEGA ID
Gene info
MeSH Data
  • Name
  • Concept
    Scope note: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
  • Tree numbers
    • E05.599.495
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