BAY 63-2521

• Catalog number
  2644-25
• Price
  Please ask
• Size
  25 mg

• Alternative_name
  Methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate; Riociguat
• Description
  BAY 63-2521 is a potent activator of soluble guanylate cyclase (sGC).
• CAS Number
  625115-55-1
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₀H₁₉FN₈O₂
• Molecular Weight
  422.42
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A potent soluble guanylate cyclase (sGC) activator
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  48 months
• PubChem CID
  11304743
• PubChem CID Link
• SMILES
  CN(C1=C(N=C(N=C1N)C2=NN(C3=C2C=CC=N3)CC4=CC=CC=C4F)N)C(=O)OC
• InChi
  InChI=1S/C20H19FN8O2/c1-28(20(30)31-2)15-16(22)25-18(26-17(15)23)14-12-7-5-9-24-19(12)29(27-14)10-11-6-3-4-8-13(11)21/h3-9H,10H2,1-2H3,(H4,22,23,25,26)
• InChi Key
  WXXSNCNJFUAIDG-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  BAY   63-2521  
• Gene symbol
  IGLVI-63, IGHV3-63, CKAP4, RNU6-63P, GTF3C5, RGPD5, MECR
• Short name
  BAY 63-2521
• Alternative name
  BAY 63-2521

Gene info

• Identity
  HGNC:5938
• Gene
  IGLVI-63
• Long gene name
  immunoglobulin lambda variable (I)-63 (pseudogene)
• Synonyms gene name
  • immunoglobulin lambda variable (I)-63
  • immunoglobulin lambda variable (I)-63 pseudogene
• Synonyms
  • IGLV(I)-63
• GenBank acession
  • D87022
• Locus
  22q11.22
• Discovery year
  2000-05-08
• Entrez gene record
  28765
• RefSeq identity
  • NG_000002
• Classification
  • Immunoglobulin lambda locus at 22q11.2
• VEGA ID
  OTTHUMG00000150855

Gene info

• Identity
  HGNC:5616
• Gene
  IGHV3-63
• Long gene name
  immunoglobulin heavy variable 3-63 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable 3-63
  • immunoglobulin heavy variable 3-63 pseudogene
• GenBank acession
  • M99681
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28415
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000151977

Gene info

• Identity
  HGNC:16991
• Gene
  CKAP4
• Long gene name
  cytoskeleton associated protein 4
• Synonyms gene name
  • cytoskeleton-associated protein 4
• Synonyms
  • P63
  • CLIMP-63
  • ERGIC-63
• GenBank acession
  • X69910
• Locus
  12q23.3
• Discovery year
  2001-11-14
• Entrez gene record
  10970
• Pubmed identfication
  • 8314870
• VEGA ID
  OTTHUMG00000170085

Gene info

• Identity
  HGNC:42553
• Gene
  RNU6-63P
• Long gene name
  RNA, U6 small nuclear 63, pseudogene
• Synonyms gene
  • RNU6-63
• Synonyms gene name
  • RNA, U6 small nuclear 63
• Locus
  13q12.2
• Discovery year
  2011-08-08
• Entrez gene record
  100873768
• RefSeq identity
  • NR_046934

Gene info

• Identity
  HGNC:4668
• Gene
  GTF3C5
• Long gene name
  general transcription factor IIIC subunit 5
• Synonyms gene name
  • general transcription factor IIIC, polypeptide 5 (63kD)
  • general transcription factor IIIC, polypeptide 5, 63kDa
• Synonyms
  • TFiiiC2-63
  • TFIIIC63
  • TFIIICepsilon
• Synonyms name
  • transcription factor IIIC, 63 kD
• GenBank acession
  • AF133124
• Locus
  9q34.13
• Discovery year
  1999-03-16
• Entrez gene record
  9328
• Pubmed identfication
  • 10373544
• RefSeq identity
  • NM_001122823
• Classification
  • General transcription factor IIIC complex subunits
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000020856

Gene info

• Identity
  HGNC:32418
• Gene
  RGPD5
• Long gene name
  RANBP2 like and GRIP domain containing 5
• Synonyms
  • RGP5
  • BS-63
  • DKFZp686I1842
• GenBank acession
  • U64675
• Locus
  2q13
• Discovery year
  2005-12-15
• Entrez gene record
  84220
• Pubmed identfication
  • 15710750
  • 15815621
• RefSeq identity
  • NM_005054
• Classification
  • Tetratricopeptide repeat domain containing
• VEGA ID
  OTTHUMG00000130985

Gene info

• Identity
  HGNC:19691
• Gene
  MECR
• Long gene name
  mitochondrial trans-2-enoyl-CoA reductase
• Synonyms
  • CGI-63
  • NRBF1
  • FASN2B
  • ETR1
• Synonyms name
  • nuclear receptor binding factor 1
  • mitochondrial 2-enoyl thioester reductase
• Locus
  1p35.3
• Discovery year
  2005-05-24
• Entrez gene record
  51102
• Pubmed identfication
  • 9795230
  • 12654921
• RefSeq identity
  • NM_016011
• VEGA ID
  OTTHUMG00000059082

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