PINK1 (C-terminal) - Blocking Peptide
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Catalog number
X2775B
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Price
Please ask
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Size
50 μg
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Category
Proteins & Peptides
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Long description
This peptide is the immunogen used to make Cat # X2760P. _x000B__x000B_Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
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Antibody come from
A fusion protein to the internal sequence GST
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Other description
Provided as 0.2µm sterile filtered solution in phosphate buffered saline with 0.08% sodium azide.
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Clone
not specified
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Antigen antibody binding interaction
PINK1 (C-terminal) - Blocking Peptide
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Antibody is raised in
see techfile
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Antibody s reacts with
Blocking Peptide to Cat # X2760P
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Antibody s reacts with these species
This antibody doesn't cross react with other species
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Antibody s specificity
No Data Available
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Application
Blocking Peptide
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Antibody s suited for
Application: Western Blots at 1:1000- 1:2,000_x000B_Optimal concentration should be evaluated by serial dilutions.
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Storage
-20ºC
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Relevant references
no information yet
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Protein number
see ncbi
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Warnings
This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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Test
You can block the antibody by the specific target amino acid sequence of peptide.
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Properties
blocking peptide
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Description
Peptides short amino acid chains or epitopes or blocking antagonists. The shortest peptides are dipeptides, consisting of 2 amino acids joined by a single peptide bond, followed by tripeptides, tetra peptides, ... till polypeptides that are long, continuous, and unbranched synthetic peptide chains. These biological oligomers and polymers can be Solid-phase peptide synthesis (SPPS), or in continue produced for custom peptide synthesis projects. The High-efficiency solid phase peptide synthesis (HE-SPPS) is give very low production costs.
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Gene target
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Gene symbol
PINK1-AS, PINK1
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Short name
PINK1 (C-terminal) - Blocking Peptide
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Technique
blocking peptide, Blocking, peptide, blocking peptides, nordc made this blocking amino acid sequence or peptide to block the gene target in a volume of 1. For western blot it is often requested to block your antibody and to see the band of the analyzed protein disappear. This is called a negative control by blocking the WB antibody. peptides
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Isotype
not specified
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Label
unlabeled
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Alternative name
phosphatase and tensin homolog induced putative kinase 1 (C-terminal) - inhibiting short protein sequence
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Alternative technique
control, peptides
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Alternative to gene target
PTEN induced putative kinase 1, PINK1 and IDBG-92922 and ENSG00000158828 and 65018, transferase activity, nuclei, Pink1 and IDBG-199773 and ENSMUSG00000028756 and 68943, PINK1 and IDBG-645657 and ENSBTAG00000006084 and 510683
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Gene info
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Identity
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Gene
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Long gene name
PINK1 antisense RNA
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Synonyms gene
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Synonyms gene name
- PINK1 antisense RNA 1 (non-protein coding)
- PINK1 antisense RNA (non-protein coding)
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Synonyms
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GenBank acession
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Locus
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Discovery year
2010-08-19
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Pubmed identfication
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Classification
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VEGA ID
Gene info
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Identity
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Gene
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Long gene name
PTEN induced kinase 1
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Synonyms gene
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Synonyms gene name
- Parkinson disease (autosomal recessive) 6
- PTEN induced putative kinase 1
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Synonyms
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GenBank acession
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Locus
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Discovery year
2001-02-08
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MicroRNA protein coding host genes
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VEGA ID
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Locus Specific Databases
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