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Granzyme B Inhibitor

Granzyme B Inhibitor is available 3 times from Biovision labs

1119-1 | Granzyme B Inhibitor Ac-IEPD-CHO size: 1 mg | 177.27 USD


K169-100 | Granzyme B Inhibitor Screening Kit (Fluorometric) size: 100 assays | 760.92 USD


1128-20C | Granzyme B Inhibitor Z-AAD-CH2Cl size: 20 ul (10 mM) | 260.47 USD

Salt Form No
Cell-Permeable? No
Handling Protect from light and moisture
Tag Line A granzyme B inhibitor
Storage Condition -20°C
Shipping Condition gel pack
Shelf Life 12 months
MSDS Available Yes
Summary • Detection method- Fluorescence ( Ex/Em = 380/500 nm ) • Applications- Screening Granzyme B inhibitors, characterize/Study Granzyme B inhibitors.
Features & Benefits • Simple, sensitive and high-throughput • Rapid and convenient • Includes Inhibitor control, Ac-IEPD-CHO.
Storage Conditions -20°C
Shipping Conditions gel pack
Shelf life 12 months
Background Granzyme B (GZMB, EC number also known as Granzyme-2 is a serine protease stored in the granules of activated cytotoxic T cells and NK cells. Upon target cell contact, Granzyme B is directionally exocytosed and with the assistance of perforin enters the target cell. With its unique substrate specificity (Granzyme B prefers an aspartic acid residue at the P1 site of its substrates), Granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. In BioVision’s Granzyme B Inhibitor Screening Kit, active human Granzyme B enzyme hydrolyzes the specific substrate to release the quench of fluorescent group, which can be detected fluorometrically at Ex/Em = 380/500 nm. In the presence of potent Granzyme B Inhibitor, the hydrolyzation of substrate will be impeded. The Kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Granzyme B inhibitors or characterize/study Granzyme B inhibitors. Inhibitor control, Ac-IEPD-CHO is included to compare the efficacy of test inhibitors.
Description Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
Alternative technique kits
Alternative to gene target v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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Granzyme B Inhibitor -
EU:+32-(0)1-658-90-45 US:+1-(408)780-0908 [email protected]
  • Granzyme
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