Human CellExp™ C-reactive/CRP, Human Recombinant
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Catalog number
7242-100
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Price
Please ask
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Size
100 ug
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Synonyms
CRP, PTX1, C-reactive protein
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Alternative_names
CRP, PTX1, C-reactive protein
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Description
Binds to phosphocholine expressed on the surface of dead or dying cells
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Recombinant
1
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Source
HEK 293 cells
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Purity by SDS PAGE
≥95%
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Assay
SDS-PAGE
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Molecular Weight
24 kDa (6×His tag at the C-terminus)
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Storage Temp
-20°C
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Shipping
Gel Pack
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Shelf Life
12 months
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Appearance
Lyophilized powder
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Physical form description
Lyophilized
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Reconstitution Instructions
Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
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Background Information
C-reactive protein (CRP) displays several functions associated with host defense including promotion of agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. It also interacts with DNA and histones and may scavenge nuclear material released from damaged circulating cells. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Therefore, CRP participates in the clearance of necrotic and apoptotic cells. It has been shown that high levels of CRP in humans are associated with an increased risk of cardiovascular diseases. CRP is a beneficial inflammatory biomarker as it is detected much faster than other markers in the blood. Studies have also demonstrated the value of CRP in predicting the development of heart failure and long-term clinical outcomes.
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Amino acid sequence
Phe 17 – Pro 224
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Handling
Centrifuge the vial prior to opening.
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Usage
For Research Use Only! Not to be used in humans
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Gene
C reactive proteins are detected by anti-CRP antibodies supplied by GENTAUR.
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Additional source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
CRP, PPIAP10
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Short name
CellExp™ C-reactive/CRP, Recombinant
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Biovision advises they will be reconstituted in a buffer soluion or culture medium for cell culture.
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Species
Humans
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Alternative name
H. sapiens CellExp™ C-reactive/C-reactive protein, pentraxin-related, H. sapiens Rec.
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Alternative technique
rec
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Alternative to gene target
C-reactive protein, pentraxin-related, PTX1, CRP and IDBG-103911 and ENSG00000132693 and 1401, protein homodimerization activity, Extracellular, Crp and IDBG-205690 and ENSMUSG00000037942 and 12944, CRP and IDBG-630749 and ENSBTAG00000013907 and 527553
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Gene info
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Identity
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Gene
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Long gene name
C-reactive protein
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Synonyms gene name
- C-reactive protein, pentraxin-related
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year
2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
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VEGA ID
Gene info
MeSH Data
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Name
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Concept
Scope note:
The initial culturing of cells derived directly from fresh TISSUES.
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Tree numbers
- E01.370.225.500.223.500
- E05.200.500.265.500
- E05.242.223.500
- E05.481.500.249.500
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Qualifiers
ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
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