BCl-2 Inhibitor, ABT-199

Alternative_name

2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4’-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methyl)piperazin-1-yl)-N-((3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino)phenyl)sulfonyl)benzamide; GDC-0199; Venetoclax
Description

Cell-permeable. A potent and selective BCl-2 inhibitor that spares platelets while achieving potent antitumor activity.
CAS Number

1257044-40-8
Structure Available

Yes
Salt Form

No
Molecular Formula

C₄₅H₅₀ClN₇O₇S
Molecular Weight

868.44
Cell Permeable

Yes
Purity

≥98% by HPLC
Solubilities

DMSO (50 mM)
Handling

Protect from light and moisture
Tag Line

A potent BCl-2 inhibitor
Storage Condition

-20°C
Shipping Condition

gel pack
Shelf Life

24 months
SMILES

N/A
InChi

N/A
InChi Key

N/A
Data Sheet Link
MSDS Available

Yes
Additional description

Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.