-
Alternative_name
(Z)-2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-1H-indole methanesulfonate
-
Description
Cell-permeable. A small molecule pan–Bcl-2 antagonist that mimics BH3-only proteins by binding to multiple antiapoptotic Bcl-2 members. GX15-070 has been shown to overcome Bcl-2–, Bcl-xl–, Bcl-w–, and Mcl-1–mediated resistance to Bax or Bak. It potently interferes with the direct interaction between Mcl-1 and Bak in intact outer mitochondrial membrane and inhibits the association between Mcl-1 and Bak in intact cells.
-
CAS Number
803712-67-6
-
Structure Available
Yes
-
Salt Form
No
-
Molecular Formula
C₂₀H₁₉N₃O
-
Molecular Weight
317.38
-
Cell Permeable
Yes
-
Purity
≥98%
-
Solubilities
DMSO (>80 mg/ml)
-
Handling
Protect from air and light
-
Tag Line
A Bcl-2 inhibitor
-
Storage Condition
-20°C
-
Shipping Condition
gel pack
-
Shelf Life
24 months
-
PubChem CID
16681698
-
-
SMILES
CC1=CC(=C(N1)C=C2C(=CC(=C3C=C4C=CC=CC4=N3)N2)OC)C.CS(=O)(=O)O
-
InChi
InChI=1S/C20H19N3O.CH4O3S/c1-12-8-13(2)21-16(12)10-19-20(24-3)11-18(23- 19)17-9-14-6-4-5-7-15(14)22-17;1-5(2,3)4/h4-11,21,23H,1-3H3;1H3,(H,2,3, 4)/b18-17-,19-10-;
-
InChi Key
ZVAGBRFUYHSUHA-LZOXOEDVSA-N
-
-
MSDS Available
Yes
-
Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
