Phloretin

• Catalog number
  9625-500
• Price
  Please ask
• Size
  500 mg

• Alternative_name
  3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-1-propanone; NSC 407292; RJC 02792
• Description
  Phloretin is a natural phenol which inhibits a variety of transporters. It inhibits the monocarboxylate transporters MCT1 and MCT2 (IC₅₀ = 28 and 14 µM, respectively), restricting the rapid transport of monocarboxylates like lactate and pyruvate across the plasma membrane. Phloretin also blocks the sodium/D-glucose cotransporter (Ki = 86 µM) and the human concentrative nucleoside transporter 3 (Ki = 32 µM). Blocks L-type Ca²⁺ channels; activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers.
• CAS Number
  60-82-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₅H₁₄O₅
• Molecular Weight
  274.27
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>25 mg/ml)
• Handling
  Protect from air and light
• Tag Line
  A natural phenol which inhibits a variety of transporters
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  36 months
• MDL Number
  MFCD00002288
• PubChem CID
  4788
• PubChem CID Link
• SMILES
  C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
• InChi
  InChI=1S/C15H14O5/c16-10-4-1-9(2-5-10)3-6-12(18)15-13(19)7-11(17)8-14(15)20/h1-2,4-5,7-8,16-17,19-20H,3,6H2
• InChi Key
  VGEREEWJJVICBM-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes

• Gene target
  Phloretin  
• Short name
  Phloretin
• Alternative name
  Phloretin

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